Detailed information of TA system TA217085

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3702301..3702953
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GF111_RS17735
• Protein ID: WP_038878669.1
• Coordinates: 3702609..3702953 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: GF111_RS17730
• Protein ID: WP_038878665.1
• Coordinates: 3702301..3702603 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
-	3702301..3702603	-	303	-	-	Antitoxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13367.40 Da
• Isoelectric Point: 10.6629

>T217085 WP_038878669.1 NZ_CP083690:c3702953-3702609 [Serratia sp. HRI]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T217085 NZ_CP113799:447250-447603 [Rhodococcus pyridinivorans]
ATGAAATGGGTGGTGGACGTCGAGCGAATCGAGGCGTGGTTGACACAACTGGACGACAATTCGTACGACCAGGTGATCGC
TGCACTCGAGCTGCTTGCGGAGAACGGCCCCATGTTGGGGCGGCCCTTGGTGGACACCGTGGAAACCTCACGTCACTCGA
ACATGAAAGAACTACGACCGGGATCACGTGGACGATCCGAACTGCGAATTCTTTTCGCCTTCGACCCGAAGCGGTCGGCG
ATCATGTTGATCGCCGGGGACAAATCAGGACAGTGGAAGAAGTGGTACAAGGTGAACATTCCAATAGCCGATGACCTCTT
CGACGAACATCTCGAGCAGTGGGAAAGGAAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT217085 WP_038878665.1 NZ_CP083690:c3702603-3702301 [Serratia sp. HRI]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT217085 NZ_CP113799:447609-447914 [Rhodococcus pyridinivorans]
ATGGCTAAGAGTCTTGACGATATGTTGGCTCAGCGACCGGCCAACCGTGAGAAGGTAGACGCTCACAAGCAGCGGATGCG
CTCGCAGGTTCGCGCGTACAAACTGAAGGAACTTCGGAAAGAGCTTCTGCTCTCCCAGGGCCAGGTCGCCGACCGTCTCG
GTGTCGGACAGAACCGGATCTCGAACATCGAGCGCGGCGATCTCGATCGGGTGCGGCTCGACACTCTGAAGCGGTACGTC
GACGCCGTGGGTGGATCGCTTCGGATCGAAGTCGAGGTGGGCGACAACCGGTACCAAATCGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7