Detailed information of TA system TA217085

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3702301..3702953
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: GF111_RS17735
• Protein ID: WP_038878669.1
• Coordinates: 3702609..3702953 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A8B4GZD7
• Locus tag: GF111_RS17730
• Protein ID: WP_038878665.1
• Coordinates: 3702301..3702603 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS17705 (GF111_17705)	3697309..3697956	-	648	WP_047729966.1	DsbA family protein	-
GF111_RS17710 (GF111_17710)	3698025..3698909	-	885	WP_033635778.1	MBL fold metallo-hydrolase	-
GF111_RS17715 (GF111_17715)	3699018..3699926	+	909	WP_015378928.1	LysR family transcriptional regulator	-
GF111_RS17720 (GF111_17720)	3699954..3700877	-	924	WP_094460604.1	LysR family transcriptional regulator	-
GF111_RS17725 (GF111_17725)	3701011..3702273	+	1263	WP_080491087.1	diaminopimelate decarboxylase	-
GF111_RS17730 (GF111_17730)	3702301..3702603	-	303	WP_038878665.1	XRE family transcriptional regulator	Antitoxin
GF111_RS17735 (GF111_17735)	3702609..3702953	-	345	WP_038878669.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GF111_RS17740 (GF111_17740)	3703113..3704132	-	1020	WP_038878671.1	HTH-type transcriptional regulator GalR	-
GF111_RS17745 (GF111_17745)	3704353..3706611	+	2259	WP_094460602.1	molybdopterin guanine dinucleotide-containing S/N-oxide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (30-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13367.40 Da
• Isoelectric Point: 10.6629

>T217085 WP_038878669.1 NZ_CP083690:c3702953-3702609 [Serratia sp. HRI]
MWQVVTVERFDDWFLALNNAQQTSILAAIFKLQTFGPQLARPHADTLHFSDAVRQLKELRIQHRGRPFRVFFAFDPQRQA
VLLCGGDKTGDQRFYQRMLPIAAMEFSHYLATRR

Nucleotide

• Length: 345 bp

>T217085 NZ_CP113799:447250-447603 [Rhodococcus pyridinivorans]
ATGAAATGGGTGGTGGACGTCGAGCGAATCGAGGCGTGGTTGACACAACTGGACGACAATTCGTACGACCAGGTGATCGC
TGCACTCGAGCTGCTTGCGGAGAACGGCCCCATGTTGGGGCGGCCCTTGGTGGACACCGTGGAAACCTCACGTCACTCGA
ACATGAAAGAACTACGACCGGGATCACGTGGACGATCCGAACTGCGAATTCTTTTCGCCTTCGACCCGAAGCGGTCGGCG
ATCATGTTGATCGCCGGGGACAAATCAGGACAGTGGAAGAAGTGGTACAAGGTGAACATTCCAATAGCCGATGACCTCTT
CGACGAACATCTCGAGCAGTGGGAAAGGAAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11111.04 Da
• Isoelectric Point: 10.3986

>AT217085 WP_038878665.1 NZ_CP083690:c3702603-3702301 [Serratia sp. HRI]
MAKPLSQLIDKLDPAVVATARQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLDVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT217085 NZ_CP113799:447609-447914 [Rhodococcus pyridinivorans]
ATGGCTAAGAGTCTTGACGATATGTTGGCTCAGCGACCGGCCAACCGTGAGAAGGTAGACGCTCACAAGCAGCGGATGCG
CTCGCAGGTTCGCGCGTACAAACTGAAGGAACTTCGGAAAGAGCTTCTGCTCTCCCAGGGCCAGGTCGCCGACCGTCTCG
GTGTCGGACAGAACCGGATCTCGAACATCGAGCGCGGCGATCTCGATCGGGTGCGGCTCGACACTCTGAAGCGGTACGTC
GACGCCGTGGGTGGATCGCTTCGGATCGAAGTCGAGGTGGGCGACAACCGGTACCAAATCGTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GZD7