Detailed information of TA system TA217066

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2479543..2479727
• Replicon: chromosome
• Accession: NZ_CP083671
• Organism: Staphylococcus aureus strain HL25870

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: K3A99_RS12380
• Protein ID: WP_000482647.1
• Coordinates: 2479620..2479727 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2479543..2479603 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3A99_RS12365	2474997..2475164	-	168	WP_001798790.1	hypothetical protein	-
K3A99_RS12370	2475395..2477128	-	1734	WP_000486511.1	ABC transporter ATP-binding protein	-
K3A99_RS12375	2477153..2478916	-	1764	WP_001064818.1	ABC transporter ATP-binding protein	-
-	2479543..2479603	+	61	-	-	Antitoxin
K3A99_RS12380	2479620..2479727	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
K3A99_RS12385	2479861..2480247	-	387	WP_000779355.1	flippase GtxA	-
K3A99_RS12390	2480514..2481656	+	1143	WP_001176859.1	glycerate kinase	-
K3A99_RS12395	2481716..2482375	+	660	WP_000831300.1	hypothetical protein	-
K3A99_RS12400	2482563..2483774	+	1212	WP_001191974.1	multidrug effflux MFS transporter	-
K3A99_RS12405	2483897..2484370	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T217066 WP_000482647.1 NZ_CP083671:c2479727-2479620 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T217066 NZ_CP113789:1858301-1858633 [Klebsiella variicola subsp. tropica]
ATGGACAGAGGGGAAATCTGGCTTGTTTCACTGGATCCGATTGCTGGCCACGAGCAAAGTGGAAAACGTCCGGTACTCAT
TGTATCGAAGGCATCGTTTAACAAGCTGACCCGACTACCGGTCGTGGTTCCCGTCACCAGCGGCGGACACTTTGCACGTA
CAGCAGGTTTCACGGTTTCACTGGAAGAAGCGGGGACCAAAACAACAGGTGTTATTCGCTGCGACCAGCCCAGAACTATC
GATATGGCGGCCCGGAACGGCAAGCGTCTGGAACGCATACCTGACGCCGTTATCAATGAGGTGCTTGCCAGGCTGGATGC
GATTCTCAGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT217066 NZ_CP083671:2479543-2479603 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin