Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2032023..2032446 | Replicon | chromosome |
| Accession | NZ_CP083671 | ||
| Organism | Staphylococcus aureus strain HL25870 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | K3A99_RS10010 | Protein ID | WP_001836226.1 |
| Coordinates | 2032195..2032446 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | K3A99_RS10005 | Protein ID | WP_000028421.1 |
| Coordinates | 2032023..2032205 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K3A99_RS09960 (2028261) | 2028261..2028605 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| K3A99_RS09965 (2028735) | 2028735..2029034 | - | 300 | WP_000988330.1 | HNH endonuclease | - |
| K3A99_RS09970 (2029266) | 2029266..2029682 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| K3A99_RS09975 (2029710) | 2029710..2029910 | - | 201 | WP_103146217.1 | DUF1514 family protein | - |
| K3A99_RS09980 (2029910) | 2029910..2030560 | - | 651 | WP_001005262.1 | hypothetical protein | - |
| K3A99_RS09985 (2030719) | 2030719..2030868 | - | 150 | WP_070030217.1 | transcriptional regulator | - |
| K3A99_RS09990 (2030881) | 2030881..2031339 | - | 459 | WP_031768021.1 | hypothetical protein | - |
| K3A99_RS09995 (2031332) | 2031332..2031484 | - | 153 | WP_031768020.1 | DUF1381 domain-containing protein | - |
| K3A99_RS10000 (2031521) | 2031521..2032030 | - | 510 | WP_031866561.1 | dUTP pyrophosphatase | - |
| K3A99_RS10005 (2032023) | 2032023..2032205 | - | 183 | WP_000028421.1 | hypothetical protein | Antitoxin |
| K3A99_RS10010 (2032195) | 2032195..2032446 | - | 252 | WP_001836226.1 | DUF1024 family protein | Toxin |
| K3A99_RS10015 (2032439) | 2032439..2032810 | - | 372 | WP_001557190.1 | hypothetical protein | - |
| K3A99_RS10020 (2032819) | 2032819..2033061 | - | 243 | WP_000131379.1 | phi PVL orf 51-like protein | - |
| K3A99_RS10025 (2033065) | 2033065..2033433 | - | 369 | WP_000101270.1 | SA1788 family PVL leukocidin-associated protein | - |
| K3A99_RS10030 (2033446) | 2033446..2033850 | - | 405 | WP_103146216.1 | RusA family crossover junction endodeoxyribonuclease | - |
| K3A99_RS10035 (2033859) | 2033859..2034077 | - | 219 | WP_053819389.1 | hypothetical protein | - |
| K3A99_RS10040 (2034084) | 2034084..2034968 | - | 885 | WP_103146215.1 | DnaD domain protein | - |
| K3A99_RS10045 (2034998) | 2034998..2035468 | - | 471 | WP_017466775.1 | single-stranded DNA-binding protein | - |
| K3A99_RS10050 (2035469) | 2035469..2036086 | - | 618 | WP_224211742.1 | MBL fold metallo-hydrolase | - |
| K3A99_RS10055 (2036167) | 2036167..2037087 | - | 921 | WP_103146214.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / hlb / groEL | 2004784..2057204 | 52420 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9457.35 Da Isoelectric Point: 3.8049
>T217061 WP_001836226.1 NZ_CP083671:c2032446-2032195 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGLPNAMQDALKEDIYLDEAVGIMTGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T217061 NZ_CP113784:3635996-3636274 [Citrobacter freundii]
ATGATCATGAACTTCAGACACAAGGGATTGCGAGATTTGTTTCTTCATGGAAGAACATCAGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCCGGTTATAAGCTAC
ATCCTCTGGTAGGTGACCGTGATGGCATATGGGCAATAACTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
ATGATCATGAACTTCAGACACAAGGGATTGCGAGATTTGTTTCTTCATGGAAGAACATCAGGCGTTATGGCGAAACATGT
CCGACGATTACGACACAGGCTTGCCGTTATTGATGCGGCAAGCAAGGTTACAGATATCAATATGCCCGGTTATAAGCTAC
ATCCTCTGGTAGGTGACCGTGATGGCATATGGGCAATAACTGTTTCAGGTAACTGGCGTATTACGTTTGAATTCGTCAAT
GGCGACGCGTACATACTGGACTACGAGGACTATCATTGA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6683.59 Da Isoelectric Point: 4.3791
>AT217061 WP_000028421.1 NZ_CP083671:c2032205-2032023 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEAQEND
Download Length: 183 bp
>AT217061 NZ_CP113784:3636274-3636558 [Citrobacter freundii]
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCTTCAACGGCAAGTCGACTATTAACCGGGAAAGCAGCCCTAACGCCTGAGATGGCGA
TTAAACTCTCTGTGGTGATTGGCAGCTCACCCGAAATGTGGTTAAACCTGCAAACTACCTGGAGTCTGGCAGAGGCCCAA
AAAAGCGTGGATATTTCACGCCTGCGTAAGCTGGCAGTACAGTGA
ATGAAGATGGCAAATCATCCCCGTCCTGGGGATATCATTCAGGAAGCGCTGGAAGAACTCAATGTCAGCCTGCGCGAGTT
TGCCAGAGCTATGGAGATTGCACCTTCAACGGCAAGTCGACTATTAACCGGGAAAGCAGCCCTAACGCCTGAGATGGCGA
TTAAACTCTCTGTGGTGATTGGCAGCTCACCCGAAATGTGGTTAAACCTGCAAACTACCTGGAGTCTGGCAGAGGCCCAA
AAAAGCGTGGATATTTCACGCCTGCGTAAGCTGGCAGTACAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|