Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4636319..4636921 Replicon chromosome
Accession NZ_CP083643
Organism Enterobacter bugandensis strain FDAARGOS_1496

Toxin (Protein)


Gene name higB Uniprot ID A0A167J774
Locus tag LA326_RS22050 Protein ID WP_047366784.1
Coordinates 4636319..4636630 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A167J796
Locus tag LA326_RS22055 Protein ID WP_047366785.1
Coordinates 4636631..4636921 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA326_RS22020 (LA326_22020) 4631978..4632721 + 744 WP_048959977.1 winged helix-turn-helix domain-containing protein -
LA326_RS22025 (LA326_22025) 4632718..4633188 + 471 WP_028014878.1 hypothetical protein -
LA326_RS22030 (LA326_22030) 4633276..4633875 + 600 WP_045260234.1 glucose-1-phosphatase -
LA326_RS22035 (LA326_22035) 4633869..4634750 + 882 WP_045260235.1 virulence factor BrkB family protein -
LA326_RS22040 (LA326_22040) 4634747..4635184 + 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
LA326_RS22045 (LA326_22045) 4635229..4636170 + 942 WP_047366783.1 fatty acid biosynthesis protein FabY -
LA326_RS22050 (LA326_22050) 4636319..4636630 + 312 WP_047366784.1 hypothetical protein Toxin
LA326_RS22055 (LA326_22055) 4636631..4636921 + 291 WP_047366785.1 NadS family protein Antitoxin
LA326_RS22060 (LA326_22060) 4636963..4637892 - 930 WP_063437456.1 formate dehydrogenase accessory protein FdhE -
LA326_RS22065 (LA326_22065) 4637889..4638524 - 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
LA326_RS22070 (LA326_22070) 4638521..4639423 - 903 WP_003861960.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12135.13 Da        Isoelectric Point: 8.8415

>T217018 WP_047366784.1 NZ_CP083643:4636319-4636630 [Enterobacter bugandensis]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDVIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTCEFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T217018 NZ_CP113540:825273-825686 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.22 Da        Isoelectric Point: 10.5888

>AT217018 WP_047366785.1 NZ_CP083643:4636631-4636921 [Enterobacter bugandensis]
MDKALFERLTQSVGQMNEIAEGQREPSRIFQIDAMKIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT217018 NZ_CP113540:825026-825292 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167J774

Antitoxin

Source ID Structure
AlphaFold DB A0A167J796

References