Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4435100..4435702 Replicon chromosome
Accession NZ_CP083641
Organism Enterobacter bugandensis strain FDAARGOS_1497

Toxin (Protein)


Gene name higB Uniprot ID A0A167J774
Locus tag LA318_RS21105 Protein ID WP_047366784.1
Coordinates 4435391..4435702 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A167J796
Locus tag LA318_RS21100 Protein ID WP_047366785.1
Coordinates 4435100..4435390 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA318_RS21085 (LA318_21085) 4432598..4433500 + 903 WP_003861960.1 formate dehydrogenase subunit beta -
LA318_RS21090 (LA318_21090) 4433497..4434132 + 636 WP_015569914.1 formate dehydrogenase cytochrome b556 subunit -
LA318_RS21095 (LA318_21095) 4434129..4435058 + 930 WP_063437456.1 formate dehydrogenase accessory protein FdhE -
LA318_RS21100 (LA318_21100) 4435100..4435390 - 291 WP_047366785.1 NadS family protein Antitoxin
LA318_RS21105 (LA318_21105) 4435391..4435702 - 312 WP_047366784.1 hypothetical protein Toxin
LA318_RS21110 (LA318_21110) 4435851..4436792 - 942 WP_047366783.1 fatty acid biosynthesis protein FabY -
LA318_RS21115 (LA318_21115) 4436837..4437274 - 438 WP_008501836.1 D-aminoacyl-tRNA deacylase -
LA318_RS21120 (LA318_21120) 4437271..4438152 - 882 WP_045260235.1 virulence factor BrkB family protein -
LA318_RS21125 (LA318_21125) 4438146..4438745 - 600 WP_045260234.1 glucose-1-phosphatase -
LA318_RS21130 (LA318_21130) 4438833..4439303 - 471 WP_028014878.1 hypothetical protein -
LA318_RS21135 (LA318_21135) 4439300..4440043 - 744 WP_048959977.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12135.13 Da        Isoelectric Point: 8.8415

>T217003 WP_047366784.1 NZ_CP083641:c4435702-4435391 [Enterobacter bugandensis]
MLFIETDIFTEDVKTLLDDDEYHRFQIFLATQPEYGDVIQNTGGLRKIRWLAGGKGKRGGVRVIYFYRTCEFEIRLLLIY
RKGIKDDLSAGEKAILKKMIERW

Download         Length: 312 bp

>T217003 NZ_CP113539:329752-330120 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10674.22 Da        Isoelectric Point: 10.5888

>AT217003 WP_047366785.1 NZ_CP083641:c4435390-4435100 [Enterobacter bugandensis]
MDKALFERLTQSVGQMNEIAEGQREPSRIFQIDAMKIKEIRQASGLSQSKFATLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVIPALSQ

Download         Length: 291 bp

>AT217003 NZ_CP113539:329534-329755 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACACGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAATTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A167J774

Antitoxin

Source ID Structure
AlphaFold DB A0A167J796

References