Detailed information of TA system TA216972

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 4316875..4317287
• Replicon: chromosome
• Accession: NZ_CP083638
• Organism: Escherichia fergusonii strain FDAARGOS_1499

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: LA347_RS20770
• Protein ID: WP_000132635.1
• Coordinates: 4316875..4317216 (-)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	4317211..4317287 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA347_RS20760 (4314288)	4314288..4315334	-	1047	WP_015953744.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-
LA347_RS20765 (4315334)	4315334..4316713	-	1380	WP_015953743.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
LA347_RS20770 (4316875)	4316875..4317216	-	342	WP_000132635.1	endoribonuclease SymE	Toxin
- (4317211)	4317211..4317287	+	77	NuclAT_15	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_15	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_15	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_15	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_16	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_16	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_16	-	Antitoxin
- (4317211)	4317211..4317287	+	77	NuclAT_16	-	Antitoxin
LA347_RS20775 (4317444)	4317444..4318952	-	1509	WP_001272443.1	restriction endonuclease subunit S	-
LA347_RS20780 (4318949)	4318949..4320538	-	1590	WP_001063202.1	type I restriction-modification system methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12310.12 Da
• Isoelectric Point: 7.8218

>T216972 WP_000132635.1 NZ_CP083638:c4317216-4316875 [Escherichia fergusonii]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEVAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T216972 NZ_CP113536:c4209497-4209213 [Salmonella enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Nucleotide

• Length: 77 bp

>AT216972 NZ_CP083638:4317211-4317287 [Escherichia fergusonii]
AGTCATAACTGCTATTCTCCTGAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin