Detailed information of TA system TA216970

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3834964..3835222
• Replicon: chromosome
• Accession: NZ_CP083638
• Organism: Escherichia fergusonii strain FDAARGOS_1499

Toxin (Protein)

• Gene name: hokA
• Uniprot ID: -
• Locus tag: LA347_RS18445
• Protein ID: WP_001135723.1
• Coordinates: 3835070..3835222 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokA
Locus tag	-
Coordinates	3834964..3835019 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA347_RS18425	3830195..3831190	-	996	WP_015953832.1	acyltransferase	-
LA347_RS18430	3831362..3831661	+	300	WP_024256552.1	YsaB family lipoprotein	-
LA347_RS18435	3831757..3832668	+	912	WP_001168544.1	glycine--tRNA ligase subunit alpha	-
LA347_RS18440	3832678..3834747	+	2070	WP_001291786.1	glycine--tRNA ligase subunit beta	-
-	3834964..3835019	-	56	-	-	Antitoxin
LA347_RS18445	3835070..3835222	+	153	WP_001135723.1	type I toxin-antitoxin system toxin HokA	Toxin
LA347_RS18450	3835199..3835270	-	72	WP_216665726.1	hypothetical protein	-
LA347_RS18455	3835381..3835752	+	372	WP_001037804.1	membrane protein insertion efficiency factor YidD	-
LA347_RS18460	3835806..3836018	-	213	WP_000014594.1	RNA chaperone/antiterminator CspA	-
LA347_RS18465	3836300..3836590	-	291	WP_000455800.1	HTH-type transcriptional regulator	-
LA347_RS18470	3836840..3838210	-	1371	WP_000184983.1	MFS transporter	-
LA347_RS18475	3838648..3839358	+	711	WP_000190514.1	DUF3053 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5899.14 Da
• Isoelectric Point: 6.9160

>T216970 WP_001135723.1 NZ_CP083638:3835070-3835222 [Escherichia fergusonii]
MPQKYGLLSLIVICFTLLFFTWMIRDSLCELHIKQESYELAAFLACKLKE

Nucleotide

• Length: 153 bp

>T216970 NZ_CP113536:3704287-3704562 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT216970 NZ_CP083638:c3835019-3834964 [Escherichia fergusonii]
GTTGAAGCATAGAGGCAGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Structures

Antitoxin