Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2826189..2826776 Replicon chromosome
Accession NC_008358
Organism Hyphomonas neptunium ATCC 15444

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag HNE_RS13185 Protein ID WP_011647644.1
Coordinates 2826495..2826776 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag HNE_RS13180 Protein ID WP_011647643.1
Coordinates 2826189..2826482 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HNE_RS13160 2821244..2821957 - 714 WP_011647640.1 rhomboid family intramembrane serine protease -
HNE_RS18755 2822072..2822446 + 375 WP_160162625.1 DUF4345 family protein -
HNE_RS13170 2822511..2825057 - 2547 WP_035592172.1 TonB-dependent receptor -
HNE_RS13175 2825506..2826045 + 540 WP_011647642.1 PAS domain-containing protein -
HNE_RS13180 2826189..2826482 - 294 WP_011647643.1 HigA family addiction module antidote protein Antitoxin
HNE_RS13185 2826495..2826776 - 282 WP_011647644.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HNE_RS13190 2826826..2828463 - 1638 WP_011647645.1 choline dehydrogenase -
HNE_RS13195 2828637..2829248 + 612 WP_011647646.1 PilZ domain-containing protein -
HNE_RS13200 2829309..2829839 - 531 WP_011647647.1 gamma carbonic anhydrase family protein -
HNE_RS13205 2830103..2830912 + 810 WP_011647648.1 PhoH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(9-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(17-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10456.99 Da        Isoelectric Point: 8.0736

>T21697 WP_011647644.1 NC_008358:c2826776-2826495 [Hyphomonas neptunium ATCC 15444]
VIQSTKGNLIEQVLEGRPGKGFPSNLFRVAVRKVAMLQAAHALDDLRVPPANRLEALKGNRTGQHSIRINDQWRICFIWG
DIGPEDVEIVDYH

Download         Length: 282 bp

>T21697 NC_008358:c2826776-2826495 [Hyphomonas neptunium ATCC 15444]
GTGATACAGAGTACCAAGGGTAATCTGATTGAGCAGGTGCTTGAAGGAAGGCCGGGCAAGGGCTTTCCTTCAAATCTGTT
CCGGGTTGCGGTGCGCAAGGTGGCCATGCTTCAGGCAGCTCATGCGCTGGATGACCTGAGGGTGCCGCCTGCCAACCGGC
TGGAAGCCCTGAAGGGAAACCGGACAGGGCAGCATTCGATCCGGATCAACGACCAGTGGCGCATCTGTTTTATCTGGGGC
GACATTGGCCCGGAAGATGTTGAGATCGTGGATTATCATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11077.02 Da        Isoelectric Point: 7.2036

>AT21697 WP_011647643.1 NC_008358:c2826482-2826189 [Hyphomonas neptunium ATCC 15444]
MTTLKVPVHPGEILRYEFLEPMGLSPIRLAKHIRVPRTRIERLIKEETALTIDTAKRLARAFGTSVEFWMNLQMSYDLLK
AEADIDVSLIEPLTAAQ

Download         Length: 294 bp

>AT21697 NC_008358:c2826482-2826189 [Hyphomonas neptunium ATCC 15444]
ATGACGACCTTGAAAGTGCCGGTCCATCCCGGTGAAATTCTCCGCTATGAGTTTCTCGAGCCGATGGGCCTCAGCCCGAT
CCGGCTTGCAAAACATATCCGCGTGCCGCGTACGCGGATTGAGCGGCTGATAAAGGAAGAGACGGCCCTGACGATCGACA
CCGCCAAACGCCTTGCCCGGGCTTTTGGCACGAGTGTCGAGTTCTGGATGAATCTTCAGATGAGCTATGACCTGCTCAAG
GCCGAGGCAGATATTGATGTCTCGCTTATCGAGCCGCTTACTGCAGCCCAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References