Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2884286..2884935 Replicon chromosome
Accession NZ_CP083630
Organism Leclercia adecarboxylata strain FDAARGOS_1505

Toxin (Protein)


Gene name higB Uniprot ID A0A855EN38
Locus tag LA332_RS13865 Protein ID WP_032616921.1
Coordinates 2884286..2884648 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A855EGE0
Locus tag LA332_RS13870 Protein ID WP_032616920.1
Coordinates 2884636..2884935 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA332_RS13845 (LA332_13845) 2879546..2880526 - 981 WP_032616924.1 LacI family DNA-binding transcriptional regulator -
LA332_RS13850 (LA332_13850) 2880602..2881744 - 1143 WP_032616923.1 Gfo/Idh/MocA family oxidoreductase -
LA332_RS13855 (LA332_13855) 2881737..2882762 - 1026 WP_032616922.1 sugar phosphate isomerase/epimerase -
LA332_RS13860 (LA332_13860) 2882774..2884015 - 1242 WP_032616942.1 MFS transporter -
LA332_RS13865 (LA332_13865) 2884286..2884648 + 363 WP_032616921.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA332_RS13870 (LA332_13870) 2884636..2884935 + 300 WP_032616920.1 helix-turn-helix transcriptional regulator Antitoxin
LA332_RS13875 (LA332_13875) 2885077..2886462 - 1386 WP_032616919.1 phenylalanine transporter -
LA332_RS13880 (LA332_13880) 2886566..2888539 - 1974 WP_032616918.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14014.97 Da        Isoelectric Point: 6.4838

>T216921 WP_032616921.1 NZ_CP083630:2884286-2884648 [Leclercia adecarboxylata]
MWEVETTDTFDKWFNHQTQALKEDVLAIMHILSEYGPQLGRPWVDTVKNSHYANMKELRIQHAGDPVRAFFAFDPVRKAI
ILCAGNKTGKNEKRFYKDMITMADAEFSDYLASKEAEWLR

Download         Length: 363 bp

>T216921 NZ_CP113519:6579-6866 [Pseudomonas sp. GOM7]
ATGACCTATAGCCTCGAATTCGATGCACGAGCACTTAAGGAGTGGCACAAGCTGGGAGACACCGTCCGCGAGCAGTTCAA
GAAAAAGCTTGCGGAGGTTCTGGTCAACCCGCGCGTCGAGGCGAATCGCCTTCACTCGCTACCCGACTGCTACAAGATCA
AGCTGCGCAGCAGTGGTTATCGCCTGGTCTATCAGGTGATCGACCATGAGGTGGTGGTGTTTGTCGTCGCGGTGGATCGA
CGTGACCGTGAGCAGGCTTACCTCAAGGCCGCTGAGCGGCTCAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11004.74 Da        Isoelectric Point: 5.8526

>AT216921 WP_032616920.1 NZ_CP083630:2884636-2884935 [Leclercia adecarboxylata]
MATLKELMAQQSQESQERIAAKVEDLRIIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPDNDPRLSTLKRYVTALG
GEVSIDVILPTGKRMAFHF

Download         Length: 300 bp

>AT216921 NZ_CP113519:6350-6589 [Pseudomonas sp. GOM7]
ATGGCCTCTATCAACATCCGTATCGACGATGAACTGAAAGAGCGGGCTTACCGTGAACTGGAAAAGCTCGGTGTCACGCC
TTCCGAGCTGATGCGCCAAACCTTGCAGTATGTTGCCGAGCGCGGCCAGTTGCCTTTCCGTCCGGTGTTGTTGACCGAGG
AGGATGAAGCCTTGATCGCCACCGTTCGTGAGCGCCTCGAAACGCCTCAGCGAGTGAAGGTTTCGCTGGATGACCTATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855EN38

Antitoxin

Source ID Structure
AlphaFold DB A0A855EGE0

References