Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 426562..427074 Replicon chromosome
Accession NZ_CP083627
Organism Streptococcus pneumoniae strain FDAARGOS_1508

Toxin (Protein)


Gene name yoeB Uniprot ID Q8DNR3
Locus tag LA346_RS02250 Protein ID WP_000924721.1
Coordinates 426562..426816 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K0ZY22
Locus tag LA346_RS02255 Protein ID WP_000388572.1
Coordinates 426820..427074 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA346_RS02235 (LA346_02235) 423663..423977 - 315 WP_000979235.1 DNA-directed RNA polymerase subunit omega -
LA346_RS02240 (LA346_02240) 424002..424628 - 627 WP_000775037.1 guanylate kinase -
LA346_RS02245 (LA346_02245) 424758..426371 - 1614 WP_000404929.1 ribonuclease Y -
LA346_RS02250 (LA346_02250) 426562..426816 - 255 WP_000924721.1 Txe/YoeB family addiction module toxin Toxin
LA346_RS02255 (LA346_02255) 426820..427074 - 255 WP_000388572.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LA346_RS02260 (LA346_02260) 427312..428409 - 1098 WP_000156323.1 nucleotidyltransferase -
LA346_RS02265 (LA346_02265) 428433..430244 - 1812 WP_001025033.1 NACHT domain-containing protein -
LA346_RS02270 (LA346_02270) 430285..431025 - 741 WP_000257068.1 class I SAM-dependent methyltransferase -
LA346_RS02275 (LA346_02275) 431345..431698 - 354 WP_001003001.1 ribosome silencing factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-75)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10115.55 Da        Isoelectric Point: 7.9716

>T216903 WP_000924721.1 NZ_CP083627:c426816-426562 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Download         Length: 255 bp

>T216903 NZ_CP113504:c1259671-1259468 [Pectobacterium brasiliense]
ATGAAAAAAATCGACTATTTGATGCGTTTGCGTAAATGCACAACCATTGACACTCTCGAACGCGTTATTGAAAAAAACAA
GTATGAACTCTCTAATGATGAGCTGGAGATGTTCTTTTCCGCAGCCGATCATCGCCTTGCAGAACTGACGATGAACAAAC
TCTACGACAAAGTCCCTACTGCAGTATGGCGATACGTTCGTTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9706.00 Da        Isoelectric Point: 4.8430

>AT216903 WP_000388572.1 NZ_CP083627:c427074-426820 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Download         Length: 255 bp

>AT216903 NZ_CP113504:c1260093-1259725 [Pectobacterium brasiliense]
ATGGATGAGTACACACCAAAACATTATGATATTGCCCAACTCAGATTCTTATGTGAGAATCTGTGTGACGAAAGCATAGC
GACGTTAGGCGATAGCAGTCACGGCTGGGTCAATGATCCAACATCTGCGATCAATCTCCAATTAAATGAACTTATTGAGC
ATATCGCTACGTTTATTCTCACATTTAAAATAAAATACCCTAACGAAAGTGAGCTTTCAGAGCAGGTTGAAAAGTATTTG
GATGATACTTACGTCTTGTTTAGCAACTATGGTATTAATGATGCTGAACTACGGCGTTGGCAGAAGTCCAAAGCAAAATT
ATTCGGAATGTTCTCAGGGGAGAACATCTGTACGCCTGCTAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7LEN4

Antitoxin

Source ID Structure
AlphaFold DB K0ZY22

References