Detailed information of TA system TA216859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 384358..384860
• Replicon: chromosome
• Accession: NZ_CP083613
• Organism: Enterobacter hormaechei subsp. oharae strain FDAARGOS_1533

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LA353_RS01755
• Protein ID: WP_047050704.1
• Coordinates: 384358..384612 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LA353_RS01760
• Protein ID: WP_047050702.1
• Coordinates: 384609..384860 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA353_RS01725 (LA353_01725)	379822..380346	-	525	WP_047050709.1	lipocalin family protein	-
LA353_RS01730 (LA353_01730)	380464..381189	+	726	WP_017383646.1	MerR family transcriptional regulator	-
LA353_RS01735 (LA353_01735)	381289..381699	+	411	WP_022650126.1	hydroxyisourate hydrolase	-
LA353_RS01740 (LA353_01740)	381802..382761	+	960	WP_047050707.1	DUF523 and DUF1722 domain-containing protein	-
LA353_RS01745 (LA353_01745)	382908..383996	+	1089	WP_047050706.1	AAA family ATPase	-
LA353_RS01750 (LA353_01750)	384127..384282	-	156	WP_154815872.1	hypothetical protein	-
LA353_RS01755 (LA353_01755)	384358..384612	-	255	WP_047050704.1	Txe/YoeB family addiction module toxin	Toxin
LA353_RS01760 (LA353_01760)	384609..384860	-	252	WP_047050702.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
LA353_RS01765 (LA353_01765)	385111..386361	-	1251	WP_047050701.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LA353_RS01770 (LA353_01770)	386368..387117	-	750	WP_047050700.1	hypothetical protein	-
LA353_RS01775 (LA353_01775)	387114..389210	-	2097	WP_047050699.1	peptidase domain-containing ABC transporter	-
LA353_RS01780 (LA353_01780)	389278..389463	-	186	WP_063159820.1	hypothetical protein	-
LA353_RS01785 (LA353_01785)	389487..389681	-	195	WP_000644465.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	363303..384860	21557

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10117.66 Da
• Isoelectric Point: 7.8747

>T216859 WP_047050704.1 NZ_CP083613:c384612-384358 [Enterobacter hormaechei subsp. oharae]
VKITWSEEAWEDYLYWQETDKRMVRKINELIKISCRTPFEGIGKPEPLKHNLAGFWSRRITSEHRMVYAITEEAILIAAC
RYHY

Nucleotide

• Length: 255 bp

>T216859 NZ_CP113494:c5447-5172 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTATGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9343.57 Da
• Isoelectric Point: 4.7854

>AT216859 WP_047050702.1 NZ_CP083613:c384860-384609 [Enterobacter hormaechei subsp. oharae]
MRVISYSEARQNLSATMVQTTEDRAPVLITRQNGESCVLMSLEEYNSLEETAYLMRSPANAKRLMNSIESLKSGSGKERD
IIE

Nucleotide

• Length: 252 bp

>AT216859 NZ_CP113494:c5731-5447 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA