Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 9831..11182 Replicon chromosome
Accession NZ_CP083612
Organism Aeromonas enteropelogenes strain FDAARGOS_1536

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag LA358_RS00065 Protein ID WP_224210505.1
Coordinates 9831..10817 (-) Length 329 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag LA358_RS00070 Protein ID WP_124243609.1
Coordinates 10868..11182 (-) Length 105 a.a.

Genomic Context

LA358_RS00035LA358_RS00050LA358_RS00055LA358_RS00060LA358_RS00040LA358_RS00045LA358_RS00065LA358_RS00070LA358_RS00075LA358_RS00080LA358_RS00085LA358_RS00090LA358_RS00095
Location: 5597..6289 (693 bp)
Type: Others
Protein ID: WP_224210502.1
Location: 8352..8687 (336 bp)
Type: Others
Protein ID: WP_042070764.1
Location: 8731..9129 (399 bp)
Type: Others
Protein ID: WP_224210504.1
Location: 9152..9711 (560 bp)
Type: Others
Protein ID: Protein_11
Location: 6369..7541 (1173 bp)
Type: Others
Protein ID: WP_224210503.1
Location: 7943..8263 (321 bp)
Type: Others
Protein ID: WP_042070761.1
Location: 9831..10817 (987 bp)
Type: Toxin
Protein ID: WP_224210505.1
Location: 10868..11182 (315 bp)
Type: Antitoxin
Protein ID: WP_124243609.1
Location: 11167..11493 (327 bp)
Type: Others
Protein ID: WP_224210506.1
Location: 12299..13435 (1137 bp)
Type: Others
Protein ID: WP_224210507.1
Location: 13546..14313 (768 bp)
Type: Others
Protein ID: WP_224210508.1
Location: 14315..14521 (207 bp)
Type: Others
Protein ID: WP_224210509.1
Location: 14518..15306 (789 bp)
Type: Others
Protein ID: WP_224210510.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LA358_RS00035 (LA358_00035)5597..6289+693WP_224210502.1B3/4 domain-containing protein-
LA358_RS00040 (LA358_00040)6369..7541-1173WP_224210503.1hypothetical protein-
LA358_RS00045 (LA358_00045)7943..8263-321WP_042070761.1hypothetical protein-
LA358_RS00050 (LA358_00050)8352..8687+336WP_042070764.1hypothetical protein-
LA358_RS00055 (LA358_00055)8731..9129+399WP_224210504.1hypothetical protein-
LA358_RS00060 (LA358_00060)9152..9711+560Protein_11GNAT family N-acetyltransferase-
LA358_RS00065 (LA358_00065)9831..10817-987WP_224210505.1HipA domain-containing proteinToxin
LA358_RS00070 (LA358_00070)10868..11182-315WP_124243609.1HipA N-terminal domain-containing proteinAntitoxin
LA358_RS00075 (LA358_00075)11167..11493-327WP_224210506.1helix-turn-helix transcriptional regulator-
LA358_RS00080 (LA358_00080)12299..13435-1137WP_224210507.12-iminoacetate synthase ThiH-
LA358_RS00085 (LA358_00085)13546..14313-768WP_224210508.1thiazole synthase-
LA358_RS00090 (LA358_00090)14315..14521-207WP_224210509.1sulfur carrier protein ThiS-
LA358_RS00095 (LA358_00095)14518..15306-789WP_224210510.1HesA/MoeB/ThiF family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(39-287)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 329 a.a.        Molecular weight: 37359.70 Da        Isoelectric Point: 6.0542

>T216855 WP_224210505.1 NZ_CP083612:c10817-9831 [Aeromonas enteropelogenes]
MEYSSAGLKKLTGTSRANPSLGFTREQFVHELPLAQKGMSISGYQPKLQMVLKDNEFSVVDHQGDYILKPSPSEFPYLAE
NEHATMTVMERLKFDVPPHGLLSFKKENPDDELEFAFIIKRFDRCENTGNPIHQEQLDGAMGISDKFGKTKSDGKQYVSY
EQVIKFLINSIDDNVKFKIELFRRIAYAYLLGNNDMHLRNFGIIHPSTGKPHLSPVYDFVSVAPYNAYFSSCYLALPLLV
KEEGDKELAFGFKTEYGEYIGVDFLELGQNMGLSPKLTEKLITDLKNESHIVESTYKDSFMPAQAIEDTLRCYRSRLERI
LVFKAALI

Download         Length: 987 bp

>T216855 NZ_CP113493:4631992-4632366 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCCCTCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12041.64 Da        Isoelectric Point: 5.6490

>AT216855 WP_124243609.1 NZ_CP083612:c11182-10868 [Aeromonas enteropelogenes]
MRRQVEVYLYGKHIGLLRQNDDGYLFEYNNGYMGPPLSLSFPVNQGRFYSDSLHPYFASLAPEGWLRKRYSQLQQLDEND
LFGILIQNGKNLIGAVQLIVENEV

Download         Length: 315 bp

>AT216855 NZ_CP113493:4631571-4631945 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAATAACGACCGCACCTGGTGGGGACTGCCCTGCACCGTGAC
GCCCTGTTTTGGGGCACGTCTGGTACAGGAAGGCAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGGCGGT
TCAGCGACGCAGATGCATACCATCCGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGTTG
TGGTTACGTTTATCTGGCGGTTTATCCGACACCGGCACCCGCAACCACCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References