Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2198686..2199379 Replicon chromosome
Accession NZ_CP083610
Organism Escherichia coli strain EC2648-Vir1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LAJ48_RS10635 Protein ID WP_000415584.1
Coordinates 2198686..2198982 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LAJ48_RS10640 Protein ID WP_000650107.1
Coordinates 2198984..2199379 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ48_RS10600 (2193774) 2193774..2194088 - 315 WP_000958598.1 putative quinol monooxygenase -
LAJ48_RS10605 (2194119) 2194119..2194700 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LAJ48_RS10610 (2195019) 2195019..2195351 + 333 WP_000917684.1 DUF2645 family protein -
LAJ48_RS10615 (2195397) 2195397..2196746 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LAJ48_RS10620 (2196743) 2196743..2197402 - 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LAJ48_RS10625 (2197554) 2197554..2197946 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LAJ48_RS10630 (2197999) 2197999..2198481 + 483 WP_000183505.1 GyrI-like domain-containing protein -
LAJ48_RS10635 (2198686) 2198686..2198982 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LAJ48_RS10640 (2198984) 2198984..2199379 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LAJ48_RS10645 (2199512) 2199512..2201119 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
LAJ48_RS10650 (2201257) 2201257..2203515 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T216834 WP_000415584.1 NZ_CP083610:2198686-2198982 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T216834 NZ_CP113493:216930-217037 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT216834 WP_000650107.1 NZ_CP083610:2198984-2199379 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT216834 NZ_CP113493:c216872-216818 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References