Detailed information of TA system TA216830

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 1664991..1665213
• Replicon: chromosome
• Accession: NZ_CP083610
• Organism: Escherichia coli strain EC2648-Vir1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1E8T8
• Locus tag: LAJ48_RS08020
• Protein ID: WP_000141634.1
• Coordinates: 1665106..1665213 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	1664991..1665057 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAJ48_RS08000	1660432..1661334	+	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-
LAJ48_RS08005	1661345..1662328	+	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
LAJ48_RS08010	1662325..1663329	+	1005	WP_000107012.1	dipeptide ABC transporter ATP-binding subunit DppF	-
LAJ48_RS08015	1663359..1664630	-	1272	WP_001295225.1	aromatic amino acid transport family protein	-
-	1664991..1665057	-	67	-	-	Antitoxin
LAJ48_RS08020	1665106..1665213	+	108	WP_000141634.1	type I toxin-antitoxin system toxic polypeptide LdrD	Toxin
LAJ48_RS08025	1665300..1666979	-	1680	WP_000191622.1	cellulose biosynthesis protein BcsG	-
LAJ48_RS08030	1666976..1667167	-	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
LAJ48_RS08035	1667164..1668735	-	1572	WP_001204931.1	cellulose biosynthesis c-di-GMP-binding protein BcsE	-
LAJ48_RS08040	1669008..1669196	+	189	WP_001063318.1	cellulose biosynthesis protein BcsR	-
LAJ48_RS08045	1669232..1669960	+	729	WP_011310329.1	cellulose biosynthesis protein BcsQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3916.72 Da
• Isoelectric Point: 9.0157

>T216830 WP_000141634.1 NZ_CP083610:1665106-1665213 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T216830 NZ_CP113487:56597-56995 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTCACGATGAAGAACAAACCCGCCAGCGTCAGGGAGCGTTTTAA
CCTGAACCAGGGGAGAATGTGTATCAGTTCGGTCACCCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGATGTTCTGGATTACGACGCTGCCGCAGCCACACACAGC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGGACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGACGGTCTGAGAATTGAAGACTGGAGCTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT216830 NZ_CP083610:c1665057-1664991 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• PDB: 5LBJ

Antitoxin