Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1075064..1075575 Replicon chromosome
Accession NZ_CP083608
Organism Macrococcus armenti strain JEK37

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU42_RS05525 Protein ID WP_133418826.1
Coordinates 1075315..1075575 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU42_RS05520 Protein ID WP_086042489.1
Coordinates 1075064..1075315 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU42_RS05485 (LAU42_05485) 1070425..1070925 - 501 WP_224184670.1 peptide-methionine (S)-S-oxide reductase MsrA -
LAU42_RS05490 (LAU42_05490) 1071048..1071989 + 942 WP_224184671.1 LCP family protein -
LAU42_RS05495 (LAU42_05495) 1072018..1072203 - 186 WP_224184672.1 2-hydroxymuconate tautomerase -
LAU42_RS05500 (LAU42_05500) 1072228..1073232 - 1005 WP_224184673.1 cation diffusion facilitator family transporter -
LAU42_RS05505 (LAU42_05505) 1073368..1073838 + 471 WP_224184674.1 GNAT family protein -
LAU42_RS05510 (LAU42_05510) 1073927..1074313 + 387 WP_224184675.1 sporulation protein -
LAU42_RS05515 (LAU42_05515) 1074514..1074972 + 459 WP_224184676.1 NUDIX domain-containing protein -
LAU42_RS05520 (LAU42_05520) 1075064..1075315 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU42_RS05525 (LAU42_05525) 1075315..1075575 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin Toxin
LAU42_RS05530 (LAU42_05530) 1075576..1076064 - 489 WP_224184677.1 GNAT family N-acetyltransferase -
LAU42_RS05535 (LAU42_05535) 1076108..1076848 + 741 WP_224184678.1 hypothetical protein -
LAU42_RS05540 (LAU42_05540) 1076858..1077748 + 891 WP_224184679.1 phosphotransferase -
LAU42_RS05545 (LAU42_05545) 1077872..1078357 + 486 WP_224184680.1 NUDIX domain-containing protein -
LAU42_RS05550 (LAU42_05550) 1078363..1079124 + 762 WP_224184681.1 hypothetical protein -
LAU42_RS05555 (LAU42_05555) 1079147..1079419 - 273 WP_224184682.1 Txe/YoeB family addiction module toxin -
LAU42_RS05560 (LAU42_05560) 1079412..1079669 - 258 WP_224184683.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LAU42_RS05565 (LAU42_05565) 1079941..1080471 + 531 WP_224184684.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(21-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10287.92 Da        Isoelectric Point: 10.1614

>T216818 WP_133418826.1 NZ_CP083608:1075315-1075575 [Macrococcus armenti]
MYKIVMKSSVKKDLKKIKNTHLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Download         Length: 261 bp

>T216818 NZ_CP113486:3390296-3390586 [Escherichia coli]
ATGAACTATGAGCTGGCGTTTGATCCGCGGGCGCTGAAAGAGTGGCAAAAACTGGGCGTGACAGTCCGGGAACAATTTAA
AAAAAAGCTTGAGGATGTGCTGAAAAGGCCGCGCAATCCATCGGCTAAACTGCGGGATTTACCGGACTGCTACAAAATTA
AGCTGCGCACACAGGGATATCGCCTGGTTTATCAGGTTAACGATAAAGAGTTGCTCGTGTTGGTGATAGCTATTGGTAAG
AGAGAGAACTCAGCCGTTTATGAAGACGCGACTAAACGGCTGGATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT216818 WP_086042489.1 NZ_CP083608:1075064-1075315 [Macrococcus armenti]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT216818 NZ_CP113486:3390064-3390306 [Escherichia coli]
ATGGCCACACTTAACGTCCGCCTGGATGACAAACTGAAAAATGAGGCTTATGCGGTGCTGGAAAAATTAAATATCACGCC
TACTGAAGCAGTGCGGCTGCTGTTTCAGTACGTTGCGGAAAATGGACGAATGCCGGTAAAAACGCTCACTGTCAGTGATA
GTGAAGAAGCCTTGTTACGCACTGTCAGGGAACGACTGGCCAACCCACAAGAGGCCATTAAGGTCCGACTGGATGAACTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References