Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1117569..1118091 Replicon chromosome
Accession NZ_CP083604
Organism Macrococcus armenti strain JEK46

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU40_RS05855 Protein ID WP_224186318.1
Coordinates 1117569..1117841 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU40_RS05860 Protein ID WP_224186319.1
Coordinates 1117834..1118091 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU40_RS05820 (LAU40_05820) 1113486..1113737 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LAU40_RS05825 (LAU40_05825) 1113737..1113997 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin -
LAU40_RS05830 (LAU40_05830) 1113998..1114447 - 450 WP_224202679.1 GNAT family N-acetyltransferase -
LAU40_RS05835 (LAU40_05835) 1114530..1115270 + 741 WP_224186314.1 hypothetical protein -
LAU40_RS05840 (LAU40_05840) 1115280..1116170 + 891 WP_224186315.1 phosphotransferase -
LAU40_RS05845 (LAU40_05845) 1116294..1116779 + 486 WP_224186316.1 NUDIX domain-containing protein -
LAU40_RS05850 (LAU40_05850) 1116785..1117546 + 762 WP_224186317.1 hypothetical protein -
LAU40_RS05855 (LAU40_05855) 1117569..1117841 - 273 WP_224186318.1 Txe/YoeB family addiction module toxin Toxin
LAU40_RS05860 (LAU40_05860) 1117834..1118091 - 258 WP_224186319.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU40_RS05865 (LAU40_05865) 1118357..1118887 + 531 WP_224186320.1 GrpB family protein -
LAU40_RS12465 1119014..1119139 + 126 WP_277602267.1 hypothetical protein -
LAU40_RS05870 (LAU40_05870) 1119175..1120788 + 1614 WP_224186321.1 ABC-F type ribosomal protection protein -
LAU40_RS05875 (LAU40_05875) 1121128..1122390 + 1263 WP_224186322.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10678.50 Da        Isoelectric Point: 9.8923

>T216816 WP_224186318.1 NZ_CP083604:c1117841-1117569 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKIKKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T216816 NZ_CP113486:3281614-3281787 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9739.83 Da        Isoelectric Point: 4.1540

>AT216816 WP_224186319.1 NZ_CP083604:c1118091-1117834 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPTNAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT216816 NZ_CP113486:3281290-3281586 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References