Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1113486..1113997 Replicon chromosome
Accession NZ_CP083604
Organism Macrococcus armenti strain JEK46

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU40_RS05825 Protein ID WP_133418826.1
Coordinates 1113737..1113997 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU40_RS05820 Protein ID WP_086042489.1
Coordinates 1113486..1113737 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU40_RS05790 (LAU40_05790) 1108802..1108987 - 186 WP_224184850.1 2-hydroxymuconate tautomerase -
LAU40_RS05795 (LAU40_05795) 1109012..1110016 - 1005 WP_224188370.1 cation diffusion facilitator family transporter -
LAU40_RS05800 (LAU40_05800) 1110178..1110564 + 387 WP_224188371.1 sporulation protein -
LAU40_RS05805 (LAU40_05805) 1110632..1111147 - 516 WP_224188372.1 DUF402 domain-containing protein -
LAU40_RS05810 (LAU40_05810) 1111240..1111698 + 459 WP_224188373.1 NUDIX domain-containing protein -
LAU40_RS05815 (LAU40_05815) 1111717..1112484 + 768 WP_224188374.1 hypothetical protein -
LAU40_RS05820 (LAU40_05820) 1113486..1113737 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU40_RS05825 (LAU40_05825) 1113737..1113997 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin Toxin
LAU40_RS05830 (LAU40_05830) 1113998..1114447 - 450 WP_224202679.1 GNAT family N-acetyltransferase -
LAU40_RS05835 (LAU40_05835) 1114530..1115270 + 741 WP_224186314.1 hypothetical protein -
LAU40_RS05840 (LAU40_05840) 1115280..1116170 + 891 WP_224186315.1 phosphotransferase -
LAU40_RS05845 (LAU40_05845) 1116294..1116779 + 486 WP_224186316.1 NUDIX domain-containing protein -
LAU40_RS05850 (LAU40_05850) 1116785..1117546 + 762 WP_224186317.1 hypothetical protein -
LAU40_RS05855 (LAU40_05855) 1117569..1117841 - 273 WP_224186318.1 Txe/YoeB family addiction module toxin -
LAU40_RS05860 (LAU40_05860) 1117834..1118091 - 258 WP_224186319.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LAU40_RS05865 (LAU40_05865) 1118357..1118887 + 531 WP_224186320.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(21-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10287.92 Da        Isoelectric Point: 10.1614

>T216815 WP_133418826.1 NZ_CP083604:1113737-1113997 [Macrococcus armenti]
MYKIVMKSSVKKDLKKIKNTHLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Download         Length: 261 bp

>T216815 NZ_CP113486:2985498-2985809 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT216815 WP_086042489.1 NZ_CP083604:1113486-1113737 [Macrococcus armenti]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT216815 NZ_CP113486:2985810-2986100 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References