216813

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1117541..1118063 Replicon chromosome
Accession NZ_CP083602
Organism Macrococcus armenti strain JEK29

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU39_RS05865 Protein ID WP_224186318.1
Coordinates 1117541..1117813 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU39_RS05870 Protein ID WP_224186319.1
Coordinates 1117806..1118063 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU39_RS05830 (LAU39_05830) 1113458..1113709 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LAU39_RS05835 (LAU39_05835) 1113709..1113969 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin -
LAU39_RS05840 (LAU39_05840) 1113970..1114458 - 489 WP_224188375.1 GNAT family N-acetyltransferase -
LAU39_RS05845 (LAU39_05845) 1114502..1115242 + 741 WP_224186314.1 hypothetical protein -
LAU39_RS05850 (LAU39_05850) 1115252..1116142 + 891 WP_224186315.1 phosphotransferase -
LAU39_RS05855 (LAU39_05855) 1116266..1116751 + 486 WP_224186316.1 NUDIX domain-containing protein -
LAU39_RS05860 (LAU39_05860) 1116757..1117518 + 762 WP_224186317.1 hypothetical protein -
LAU39_RS05865 (LAU39_05865) 1117541..1117813 - 273 WP_224186318.1 Txe/YoeB family addiction module toxin Toxin
LAU39_RS05870 (LAU39_05870) 1117806..1118063 - 258 WP_224186319.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU39_RS05875 (LAU39_05875) 1118329..1118859 + 531 WP_224186320.1 GrpB family protein -
LAU39_RS05880 (LAU39_05880) 1119147..1120760 + 1614 WP_224186321.1 ABC-F type ribosomal protection protein -
LAU39_RS05885 (LAU39_05885) 1121100..1122362 + 1263 WP_224186322.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10678.50 Da        Isoelectric Point: 9.8923

>T216813 WP_224186318.1 NZ_CP083602:c1117813-1117541 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKIKKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T216813 NZ_CP113486:c2566853-2566746 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9739.83 Da        Isoelectric Point: 4.1540

>AT216813 WP_224186319.1 NZ_CP083602:c1118063-1117806 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPTNAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT216813 NZ_CP113486:2566911-2566965 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References