Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe(toxin)
Location 1113458..1113969 Replicon chromosome
Accession NZ_CP083602
Organism Macrococcus armenti strain JEK29

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU39_RS05835 Protein ID WP_133418826.1
Coordinates 1113709..1113969 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU39_RS05830 Protein ID WP_086042489.1
Coordinates 1113458..1113709 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU39_RS05800 (LAU39_05800) 1108774..1108959 - 186 WP_224184850.1 2-hydroxymuconate tautomerase -
LAU39_RS05805 (LAU39_05805) 1108984..1109988 - 1005 WP_224188370.1 cation diffusion facilitator family transporter -
LAU39_RS05810 (LAU39_05810) 1110150..1110536 + 387 WP_224188371.1 sporulation protein -
LAU39_RS05815 (LAU39_05815) 1110604..1111119 - 516 WP_224188372.1 DUF402 domain-containing protein -
LAU39_RS05820 (LAU39_05820) 1111212..1111670 + 459 WP_224188373.1 NUDIX domain-containing protein -
LAU39_RS05825 (LAU39_05825) 1111689..1112456 + 768 WP_224188374.1 hypothetical protein -
LAU39_RS05830 (LAU39_05830) 1113458..1113709 + 252 WP_086042489.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU39_RS05835 (LAU39_05835) 1113709..1113969 + 261 WP_133418826.1 Txe/YoeB family addiction module toxin Toxin
LAU39_RS05840 (LAU39_05840) 1113970..1114458 - 489 WP_224188375.1 GNAT family N-acetyltransferase -
LAU39_RS05845 (LAU39_05845) 1114502..1115242 + 741 WP_224186314.1 hypothetical protein -
LAU39_RS05850 (LAU39_05850) 1115252..1116142 + 891 WP_224186315.1 phosphotransferase -
LAU39_RS05855 (LAU39_05855) 1116266..1116751 + 486 WP_224186316.1 NUDIX domain-containing protein -
LAU39_RS05860 (LAU39_05860) 1116757..1117518 + 762 WP_224186317.1 hypothetical protein -
LAU39_RS05865 (LAU39_05865) 1117541..1117813 - 273 WP_224186318.1 Txe/YoeB family addiction module toxin -
LAU39_RS05870 (LAU39_05870) 1117806..1118063 - 258 WP_224186319.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LAU39_RS05875 (LAU39_05875) 1118329..1118859 + 531 WP_224186320.1 GrpB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(21-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10287.92 Da        Isoelectric Point: 10.1614

>T216812 WP_133418826.1 NZ_CP083602:1113709-1113969 [Macrococcus armenti]
MYKIVMKSSVKKDLKKIKNTHLETNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Download         Length: 261 bp

>T216812 NZ_CP113486:c2566369-2566262 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9590.65 Da        Isoelectric Point: 4.0373

>AT216812 WP_086042489.1 NZ_CP083602:1113458-1113709 [Macrococcus armenti]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT216812 NZ_CP113486:2566417-2566483 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References