Detailed information of TA system TA216807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1132262..1132784
• Replicon: chromosome
• Accession: NZ_CP083595
• Organism: Macrococcus armenti strain 17Msa1131

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: LAU43_RS05940
• Protein ID: WP_224184862.1
• Coordinates: 1132262..1132534 (-)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: LAU43_RS05945
• Protein ID: WP_111745011.1
• Coordinates: 1132527..1132784 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAU43_RS05900 (LAU43_05900)	1128183..1128434	+	252	WP_224184855.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
LAU43_RS05905 (LAU43_05905)	1128434..1128693	+	260	Protein_1172	Txe/YoeB family addiction module toxin	-
LAU43_RS05910 (LAU43_05910)	1128694..1129050	-	357	WP_224184856.1	GNAT family N-acetyltransferase	-
LAU43_RS05915 (LAU43_05915)	1129019..1129180	-	162	WP_224184857.1	hypothetical protein	-
LAU43_RS05920 (LAU43_05920)	1129223..1129963	+	741	WP_224184858.1	hypothetical protein	-
LAU43_RS05925 (LAU43_05925)	1129973..1130863	+	891	WP_224184859.1	phosphotransferase	-
LAU43_RS05930 (LAU43_05930)	1130987..1131472	+	486	WP_224184860.1	NUDIX domain-containing protein	-
LAU43_RS05935 (LAU43_05935)	1131478..1132239	+	762	WP_224184861.1	hypothetical protein	-
LAU43_RS05940 (LAU43_05940)	1132262..1132534	-	273	WP_224184862.1	Txe/YoeB family addiction module toxin	Toxin
LAU43_RS05945 (LAU43_05945)	1132527..1132784	-	258	WP_111745011.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LAU43_RS05950 (LAU43_05950)	1133056..1134057	+	1002	WP_224184863.1	GNAT family N-acetyltransferase	-
LAU43_RS05955 (LAU43_05955)	1134081..1134575	+	495	WP_224184864.1	isochorismatase family cysteine hydrolase	-
LAU43_RS05960 (LAU43_05960)	1134810..1136072	+	1263	WP_224184865.1	Y-family DNA polymerase	-
LAU43_RS05965 (LAU43_05965)	1136190..1137230	+	1041	WP_224184866.1	M42 family metallopeptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-69)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10664.43 Da
• Isoelectric Point: 9.7524

>T216807 WP_224184862.1 NZ_CP083595:c1132534-1132262 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Nucleotide

• Length: 273 bp

>T216807 NZ_CP113486:c1761675-1761268 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCCTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9709.80 Da
• Isoelectric Point: 4.1540

>AT216807 WP_111745011.1 NZ_CP083595:c1132784-1132527 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Nucleotide

• Length: 258 bp

>AT216807 NZ_CP113486:c1761922-1761656 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGATGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA