Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1097620..1098142 Replicon chromosome
Accession NZ_CP083592
Organism Macrococcus armenti strain 19Msa0966

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag LAU41_RS05705 Protein ID WP_224199953.1
Coordinates 1097620..1097892 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag LAU41_RS05710 Protein ID WP_224186319.1
Coordinates 1097885..1098142 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAU41_RS05670 (LAU41_05670) 1093452..1093637 + 186 Protein_1119 Txe/YoeB family addiction module toxin -
LAU41_RS05675 (LAU41_05675) 1093641..1094126 - 486 WP_224199947.1 GNAT family N-acetyltransferase -
LAU41_RS05680 (LAU41_05680) 1094169..1094909 + 741 WP_224199948.1 hypothetical protein -
LAU41_RS05685 (LAU41_05685) 1095265..1095873 + 609 WP_224199949.1 ATP-binding protein -
LAU41_RS05690 (LAU41_05690) 1095910..1096173 + 264 WP_224199950.1 hypothetical protein -
LAU41_RS05695 (LAU41_05695) 1096345..1096830 + 486 WP_224199951.1 NUDIX domain-containing protein -
LAU41_RS05700 (LAU41_05700) 1096836..1097597 + 762 WP_224199952.1 hypothetical protein -
LAU41_RS05705 (LAU41_05705) 1097620..1097892 - 273 WP_224199953.1 Txe/YoeB family addiction module toxin Toxin
LAU41_RS05710 (LAU41_05710) 1097885..1098142 - 258 WP_224186319.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LAU41_RS05715 (LAU41_05715) 1098408..1098938 + 531 WP_224186320.1 GrpB family protein -
LAU41_RS11920 1099065..1099190 + 126 WP_277602267.1 hypothetical protein -
LAU41_RS05720 (LAU41_05720) 1099226..1100839 + 1614 WP_224199954.1 ABC-F type ribosomal protection protein -
LAU41_RS05725 (LAU41_05725) 1101179..1102441 + 1263 WP_224199955.1 Y-family DNA polymerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(12-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10664.47 Da        Isoelectric Point: 9.8923

>T216803 WP_224199953.1 NZ_CP083592:c1097892-1097620 [Macrococcus armenti]
MPKKKILFYSGGFEDYTYWQTNDKTVLKKIKKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRVTHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T216803 NZ_CP113486:c732383-732129 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9739.83 Da        Isoelectric Point: 4.1540

>AT216803 WP_224186319.1 NZ_CP083592:c1098142-1097885 [Macrococcus armenti]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPTNAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT216803 NZ_CP113486:c732631-732380 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References