Detailed information of TA system TA216760

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4960843..4961264
• Replicon: chromosome
• Accession: NZ_CP083575
• Organism: Xanthomonas phaseoli pv. manihotis strain CHN01

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A3Q9Q4S9
• Locus tag: K9838_RS21675
• Protein ID: WP_017156024.1
• Coordinates: 4961151..4961264 (-)
• Length: 38 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: K9838_RS21670
• Protein ID: WP_017156025.1
• Coordinates: 4960843..4961133 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9838_RS21645 (K9838_21635)	4956155..4956487	+	333	WP_003482333.1	hypothetical protein	-
K9838_RS21655 (K9838_21645)	4956822..4958747	+	1926	WP_017156028.1	M61 family metallopeptidase	-
K9838_RS21660 (K9838_21650)	4958815..4958994	+	180	WP_017156027.1	hypothetical protein	-
K9838_RS21665 (K9838_21655)	4959097..4960488	-	1392	WP_017156026.1	type III secretion system effector XopQ	-
K9838_RS21670 (K9838_21660)	4960843..4961133	-	291	WP_017156025.1	HigA family addiction module antitoxin	Antitoxin
K9838_RS21675 (K9838_21665)	4961151..4961264	-	114	WP_017156024.1	hypothetical protein	Toxin
K9838_RS21680 (K9838_21670)	4961529..4963943	-	2415	WP_017156023.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (1-94)

Sequences

Toxin

Protein

• Length: 38 a.a.
• Molecular weight: 4677.41 Da
• Isoelectric Point: 9.1273

>T216760 WP_017156024.1 NZ_CP083575:c4961264-4961151 [Xanthomonas phaseoli pv. manihotis]
MKGERRGQYRIRINDRWRICVRWMEGDVVQVEIIDYH

Nucleotide

• Length: 114 bp

>T216760 NZ_CP113364:3581006-3581251 [Salmonella enterica subsp. enterica]
ATGAATGCCTCCGGCGCCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCGG
CGACTGCCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACGGTGAAGATTTCGGACGGGTGTATTGTGCTAATGG
CGGACGGTAACGAGGTGCAGAAGCTGTGCGAACAGCTTTACAAGGCTGAACAGGTAGTTAAGGGGATGTGGGACGTGATT
GTTTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10387.09 Da
• Isoelectric Point: 9.0188

>AT216760 WP_017156025.1 NZ_CP083575:c4961133-4960843 [Xanthomonas phaseoli pv. manihotis]
MTVLPNIHPGAILLEEFLQPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTFERFWLGLQADDELEQA
HRALGDLPARIKRLAA

Nucleotide

• Length: 291 bp

>AT216760 NZ_CP113364:c3581156-3580849 [Salmonella enterica subsp. enterica]
CAATACACCCGTCCGAAATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGG
ATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGCATTCATATTTGCTGA
CTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCATGG
CACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3Q9Q4S9