Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 91061..91315 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP083531 | ||
| Organism | Escherichia coli strain elppa2 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | K9U05_RS23905 | Protein ID | WP_001312851.1 |
| Coordinates | 91061..91210 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 91254..91315 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U05_RS23875 (86400) | 86400..89348 | + | 2949 | Protein_78 | Tn3-like element Tn3 family transposase | - |
| K9U05_RS23880 (89281) | 89281..89746 | - | 466 | Protein_79 | plasmid replication initiator RepA | - |
| K9U05_RS23885 (89739) | 89739..90221 | - | 483 | WP_001273588.1 | hypothetical protein | - |
| K9U05_RS23890 (90214) | 90214..90261 | - | 48 | WP_229471593.1 | hypothetical protein | - |
| K9U05_RS23895 (90252) | 90252..90503 | + | 252 | WP_228596070.1 | replication protein RepA | - |
| K9U05_RS23900 (90520) | 90520..90777 | - | 258 | WP_000083845.1 | replication regulatory protein RepA | - |
| K9U05_RS23905 (91061) | 91061..91210 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (91254) | 91254..91315 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (91254) | 91254..91315 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (91254) | 91254..91315 | + | 62 | NuclAT_1 | - | Antitoxin |
| - (91254) | 91254..91315 | + | 62 | NuclAT_1 | - | Antitoxin |
| K9U05_RS23910 (91891) | 91891..92103 | - | 213 | WP_001299730.1 | ANR family transcriptional regulator | - |
| K9U05_RS23915 (92239) | 92239..92799 | - | 561 | WP_000139315.1 | fertility inhibition protein FinO | - |
| K9U05_RS23920 (92902) | 92902..93762 | - | 861 | WP_000704513.1 | alpha/beta hydrolase | - |
| K9U05_RS23925 (93821) | 93821..94567 | - | 747 | WP_228613795.1 | conjugal transfer pilus acetylase TraX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | sitABCD / dfrA14 | iutA / iucD / iucC / iucB / iucA / iroB / iroC / iroD / iroE / iroN / vat | 1..155994 | 155994 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T216748 WP_001312851.1 NZ_CP083531:c91210-91061 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T216748 NZ_CP113267:c1011034-1010780 [Streptococcus pneumoniae]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGGTCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA
Antitoxin
Download Length: 62 bp
>AT216748 NZ_CP083531:91254-91315 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
