Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 232893..233628 Replicon chromosome
Accession NC_008313
Organism Ralstonia eutropha H16

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7T4FXN9
Locus tag H16_RS01075 Protein ID WP_041687119.1
Coordinates 232893..233195 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID R7XDR2
Locus tag H16_RS01080 Protein ID WP_010813310.1
Coordinates 233227..233628 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H16_RS01055 228462..229310 + 849 WP_011614406.1 thioesterase family protein -
H16_RS01060 229324..230583 - 1260 WP_010813306.1 muropeptide transporter -
H16_RS01065 230734..231696 + 963 WP_010813307.1 M48 family metallopeptidase -
H16_RS01070 231767..232714 - 948 WP_010813308.1 N-acetyl-gamma-glutamyl-phosphate reductase -
H16_RS01075 232893..233195 + 303 WP_041687119.1 type II toxin-antitoxin system MqsR family toxin Toxin
H16_RS01080 233227..233628 + 402 WP_010813310.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
H16_RS01085 233638..234414 - 777 WP_011614408.1 exodeoxyribonuclease III -
H16_RS01090 234442..235128 + 687 WP_010813312.1 orotate phosphoribosyltransferase -
H16_RS01095 235290..236564 + 1275 WP_010813313.1 patatin-like phospholipase family protein -
H16_RS01100 236579..237388 - 810 WP_011614411.1 polyphosphate kinase 2 family protein -
H16_RS01105 237496..238362 - 867 WP_011614412.1 diaminopimelate epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(7-98)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11199.02 Da        Isoelectric Point: 8.7037

>T21672 WP_041687119.1 NC_008313:232893-233195 [Cupriavidus necator H16]
ICAGKGTAHDPLWRVRELIAAGRVSLTMAAFQGARNMCLTRGDVLDVVARIQPADFYKSMTTYVDHTVWQDVYRPCTSYG
AIYLKLTVTEEVLIVSFKAR

Download         Length: 303 bp

>T21672 NC_008313:232893-233195 [Cupriavidus necator H16]
ATTTGCGCGGGGAAGGGAACGGCGCATGACCCGCTGTGGCGGGTCCGGGAGTTGATTGCGGCAGGGCGGGTCAGCTTGAC
GATGGCAGCGTTCCAGGGCGCCAGGAACATGTGTCTCACCCGCGGCGACGTCCTTGATGTAGTCGCCAGGATCCAGCCCG
CCGACTTCTACAAAAGCATGACGACCTACGTCGACCATACCGTCTGGCAGGATGTGTATCGCCCATGCACATCGTATGGA
GCGATATACCTGAAGCTGACGGTGACCGAGGAAGTCCTGATTGTGTCGTTCAAGGCGCGCTAG

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14845.05 Da        Isoelectric Point: 5.8009

>AT21672 WP_010813310.1 NC_008313:233227-233628 [Cupriavidus necator H16]
MRCPVCGGAELERGRKDFVYTYRGESTVIEAVLADWCAQCGEGVLGQEEEERIGPLALAFNKQVNASLVDPTYIMQVRKK
LHLDQREAAEIFGGGVNAFSRYETGRTKPPLALVKLLRLLDRHPELLEEVRAA

Download         Length: 402 bp

>AT21672 NC_008313:233227-233628 [Cupriavidus necator H16]
ATGCGATGCCCGGTATGTGGAGGCGCCGAACTCGAAAGGGGGCGGAAAGACTTTGTCTATACCTACCGTGGCGAGTCCAC
GGTAATCGAAGCGGTCCTTGCCGACTGGTGTGCTCAGTGTGGAGAAGGTGTGCTGGGCCAGGAAGAGGAAGAGCGGATCG
GACCGCTGGCGCTCGCCTTCAACAAGCAAGTCAACGCCTCGCTTGTCGATCCGACTTACATCATGCAAGTCCGCAAGAAA
CTCCACCTCGACCAGCGCGAAGCCGCAGAGATCTTCGGCGGCGGGGTCAATGCATTCTCGCGCTACGAGACTGGCCGGAC
CAAGCCGCCGCTTGCGCTGGTAAAACTGCTCAGGCTGCTGGACCGCCACCCGGAACTGCTTGAGGAGGTCCGGGCGGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T4FXN9

Antitoxin

Source ID Structure
AlphaFold DB A0A7T4FWF9

References