Detailed information of TA system TA216698

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3810910..3811168
• Replicon: chromosome
• Accession: NZ_CP083512
• Organism: Escherichia coli strain elppa4

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: K9U07_RS18500
• Protein ID: WP_000809168.1
• Coordinates: 3810910..3811062 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3811111..3811168 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U07_RS18480	3806152..3806865	-	714	WP_001102367.1	acidic protein MsyB	-
K9U07_RS18485	3806891..3807295	-	405	WP_000843579.1	DUF2541 family protein	-
K9U07_RS18490	3807671..3809587	+	1917	WP_000516135.1	molecular chaperone DnaK	-
K9U07_RS18495	3809676..3810806	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
K9U07_RS18500	3810910..3811062	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	3811111..3811168	+	58	-	-	Antitoxin
K9U07_RS18505	3811648..3812814	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
K9U07_RS18510	3812880..3813779	+	900	WP_001300855.1	transcriptional activator NhaR	-
K9U07_RS18515	3813817..3814776	-	960	WP_000871682.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T216698 WP_000809168.1 NZ_CP083512:c3811062-3810910 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T216698 NZ_CP113217:c220592-220176 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT216698 NZ_CP083512:3811111-3811168 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin