Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-orzP/Ldr(toxin)
Location 72550..72771 Replicon chromosome
Accession NZ_CP083512
Organism Escherichia coli strain elppa4

Toxin (Protein)


Gene name ldrD Uniprot ID A0A7A6GBY2
Locus tag K9U07_RS00380 Protein ID WP_000176714.1
Coordinates 72550..72657 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name orzP
Locus tag -
Coordinates 72705..72771 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U07_RS00355 (68395) 68395..69477 + 1083 WP_000804726.1 peptide chain release factor 1 -
K9U07_RS00360 (69477) 69477..70310 + 834 WP_000456477.1 peptide chain release factor N(5)-glutamine methyltransferase -
K9U07_RS00365 (70307) 70307..70699 + 393 WP_000200381.1 invasion regulator SirB2 -
K9U07_RS00370 (70703) 70703..71512 + 810 WP_001257044.1 invasion regulator SirB1 -
K9U07_RS00375 (71548) 71548..72402 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
K9U07_RS00380 (72550) 72550..72657 - 108 WP_000176714.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (72707) 72707..72770 + 64 NuclAT_24 - -
- (72707) 72707..72770 + 64 NuclAT_24 - -
- (72707) 72707..72770 + 64 NuclAT_24 - -
- (72707) 72707..72770 + 64 NuclAT_24 - -
- (72707) 72707..72770 + 64 NuclAT_26 - -
- (72707) 72707..72770 + 64 NuclAT_26 - -
- (72707) 72707..72770 + 64 NuclAT_26 - -
- (72707) 72707..72770 + 64 NuclAT_26 - -
- (72707) 72707..72770 + 64 NuclAT_28 - -
- (72707) 72707..72770 + 64 NuclAT_28 - -
- (72707) 72707..72770 + 64 NuclAT_28 - -
- (72707) 72707..72770 + 64 NuclAT_28 - -
- (72707) 72707..72770 + 64 NuclAT_30 - -
- (72707) 72707..72770 + 64 NuclAT_30 - -
- (72707) 72707..72770 + 64 NuclAT_30 - -
- (72707) 72707..72770 + 64 NuclAT_30 - -
- (72707) 72707..72770 + 64 NuclAT_32 - -
- (72707) 72707..72770 + 64 NuclAT_32 - -
- (72707) 72707..72770 + 64 NuclAT_32 - -
- (72707) 72707..72770 + 64 NuclAT_32 - -
- (72707) 72707..72770 + 64 NuclAT_34 - -
- (72707) 72707..72770 + 64 NuclAT_34 - -
- (72707) 72707..72770 + 64 NuclAT_34 - -
- (72707) 72707..72770 + 64 NuclAT_34 - -
- (72705) 72705..72771 + 67 NuclAT_11 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_11 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_11 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_11 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_13 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_13 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_13 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_13 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_15 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_15 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_15 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_15 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_17 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_17 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_17 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_17 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_19 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_19 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_19 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_19 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_21 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_21 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_21 - Antitoxin
- (72705) 72705..72771 + 67 NuclAT_21 - Antitoxin
- (72707) 72707..72772 + 66 NuclAT_36 - -
- (72707) 72707..72772 + 66 NuclAT_36 - -
- (72707) 72707..72772 + 66 NuclAT_36 - -
- (72707) 72707..72772 + 66 NuclAT_36 - -
- (72707) 72707..72772 + 66 NuclAT_38 - -
- (72707) 72707..72772 + 66 NuclAT_38 - -
- (72707) 72707..72772 + 66 NuclAT_38 - -
- (72707) 72707..72772 + 66 NuclAT_38 - -
- (72707) 72707..72772 + 66 NuclAT_40 - -
- (72707) 72707..72772 + 66 NuclAT_40 - -
- (72707) 72707..72772 + 66 NuclAT_40 - -
- (72707) 72707..72772 + 66 NuclAT_40 - -
- (72707) 72707..72772 + 66 NuclAT_42 - -
- (72707) 72707..72772 + 66 NuclAT_42 - -
- (72707) 72707..72772 + 66 NuclAT_42 - -
- (72707) 72707..72772 + 66 NuclAT_42 - -
K9U07_RS00385 (73085) 73085..73192 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein -
- (73245) 73245..73306 + 62 NuclAT_23 - -
- (73245) 73245..73306 + 62 NuclAT_23 - -
- (73245) 73245..73306 + 62 NuclAT_23 - -
- (73245) 73245..73306 + 62 NuclAT_23 - -
- (73245) 73245..73306 + 62 NuclAT_25 - -
- (73245) 73245..73306 + 62 NuclAT_25 - -
- (73245) 73245..73306 + 62 NuclAT_25 - -
- (73245) 73245..73306 + 62 NuclAT_25 - -
- (73245) 73245..73306 + 62 NuclAT_27 - -
- (73245) 73245..73306 + 62 NuclAT_27 - -
- (73245) 73245..73306 + 62 NuclAT_27 - -
- (73245) 73245..73306 + 62 NuclAT_27 - -
- (73245) 73245..73306 + 62 NuclAT_29 - -
- (73245) 73245..73306 + 62 NuclAT_29 - -
- (73245) 73245..73306 + 62 NuclAT_29 - -
- (73245) 73245..73306 + 62 NuclAT_29 - -
- (73245) 73245..73306 + 62 NuclAT_31 - -
- (73245) 73245..73306 + 62 NuclAT_31 - -
- (73245) 73245..73306 + 62 NuclAT_31 - -
- (73245) 73245..73306 + 62 NuclAT_31 - -
- (73245) 73245..73306 + 62 NuclAT_33 - -
- (73245) 73245..73306 + 62 NuclAT_33 - -
- (73245) 73245..73306 + 62 NuclAT_33 - -
- (73245) 73245..73306 + 62 NuclAT_33 - -
- (73245) 73245..73307 + 63 NuclAT_12 - -
- (73245) 73245..73307 + 63 NuclAT_12 - -
- (73245) 73245..73307 + 63 NuclAT_12 - -
- (73245) 73245..73307 + 63 NuclAT_12 - -
- (73245) 73245..73307 + 63 NuclAT_14 - -
- (73245) 73245..73307 + 63 NuclAT_14 - -
- (73245) 73245..73307 + 63 NuclAT_14 - -
- (73245) 73245..73307 + 63 NuclAT_14 - -
- (73245) 73245..73307 + 63 NuclAT_16 - -
- (73245) 73245..73307 + 63 NuclAT_16 - -
- (73245) 73245..73307 + 63 NuclAT_16 - -
- (73245) 73245..73307 + 63 NuclAT_16 - -
- (73245) 73245..73307 + 63 NuclAT_18 - -
- (73245) 73245..73307 + 63 NuclAT_18 - -
- (73245) 73245..73307 + 63 NuclAT_18 - -
- (73245) 73245..73307 + 63 NuclAT_18 - -
- (73245) 73245..73307 + 63 NuclAT_20 - -
- (73245) 73245..73307 + 63 NuclAT_20 - -
- (73245) 73245..73307 + 63 NuclAT_20 - -
- (73245) 73245..73307 + 63 NuclAT_20 - -
- (73245) 73245..73307 + 63 NuclAT_22 - -
- (73245) 73245..73307 + 63 NuclAT_22 - -
- (73245) 73245..73307 + 63 NuclAT_22 - -
- (73245) 73245..73307 + 63 NuclAT_22 - -
- (73245) 73245..73308 + 64 NuclAT_35 - -
- (73245) 73245..73308 + 64 NuclAT_35 - -
- (73245) 73245..73308 + 64 NuclAT_35 - -
- (73245) 73245..73308 + 64 NuclAT_35 - -
- (73245) 73245..73308 + 64 NuclAT_37 - -
- (73245) 73245..73308 + 64 NuclAT_37 - -
- (73245) 73245..73308 + 64 NuclAT_37 - -
- (73245) 73245..73308 + 64 NuclAT_37 - -
- (73245) 73245..73308 + 64 NuclAT_39 - -
- (73245) 73245..73308 + 64 NuclAT_39 - -
- (73245) 73245..73308 + 64 NuclAT_39 - -
- (73245) 73245..73308 + 64 NuclAT_39 - -
- (73245) 73245..73308 + 64 NuclAT_41 - -
- (73245) 73245..73308 + 64 NuclAT_41 - -
- (73245) 73245..73308 + 64 NuclAT_41 - -
- (73245) 73245..73308 + 64 NuclAT_41 - -
K9U07_RS00390 (73598) 73598..74698 - 1101 WP_000063608.1 sodium-potassium/proton antiporter ChaA -
K9U07_RS00395 (74968) 74968..75198 + 231 WP_001146444.1 putative cation transport regulator ChaB -
K9U07_RS00400 (75356) 75356..76051 + 696 WP_001469092.1 glutathione-specific gamma-glutamylcyclotransferase -
K9U07_RS00405 (76095) 76095..76448 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4061.82 Da        Isoelectric Point: 11.4779

>T216676 WP_000176714.1 NZ_CP083512:c72657-72550 [Escherichia coli]
MTLTQFAMTFWHDLATPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

>T216676 NZ_CP113211:c4557058-4556525 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 67 bp

>AT216676 NZ_CP083512:72705-72771 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7A6GBY2

Antitoxin

Download structure file

References