Detailed information of TA system TA216673

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 275..701
• Replicon: plasmid unnamed4
• Accession: NZ_CP083507
• Organism: Escherichia coli strain elppa5

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: K9U08_RS25740
• Protein ID: WP_001372321.1
• Coordinates: 275..400 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	477..701 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U08_RS25740 (275)	275..400	-	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
K9U08_RS25745 (342)	342..491	-	150	Protein_1	plasmid maintenance protein Mok	-
- (479)	479..544	+	66	NuclAT_0	-	-
- (479)	479..544	+	66	NuclAT_0	-	-
- (479)	479..544	-	66	NuclAT_1	-	-
- (477)	477..701	+	225	NuclAT_0	-	-
- (477)	477..701	-	225	NuclAT_0	-	Antitoxin
- (477)	477..701	-	225	NuclAT_0	-	Antitoxin
- (477)	477..701	-	225	NuclAT_0	-	Antitoxin
- (477)	477..701	-	225	NuclAT_0	-	Antitoxin
K9U08_RS25750 (513)	513..701	+	189	WP_001299721.1	hypothetical protein	-
K9U08_RS25755 (670)	670..1432	-	763	Protein_3	plasmid SOS inhibition protein A	-
K9U08_RS25760 (1429)	1429..1863	-	435	WP_000845901.1	conjugation system SOS inhibitor PsiB	-
K9U08_RS25765 (1918)	1918..3876	-	1959	WP_001145469.1	ParB/RepB/Spo0J family partition protein	-
K9U08_RS25770 (3935)	3935..4168	-	234	WP_000006004.1	DUF905 domain-containing protein	-
K9U08_RS25775 (4533)	4533..5354	+	822	WP_001272932.1	abortive infection system antitoxin AbiGi family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T216673 WP_001372321.1 NZ_CP083507:c400-275 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T216673 NZ_CP113211:1867494-1867596 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 225 bp

>AT216673 NZ_CP083507:c701-477 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin