Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2571287..2571980 Replicon chromosome
Accession NZ_CP083503
Organism Escherichia coli strain elppa5

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K9U08_RS12745 Protein ID WP_000415584.1
Coordinates 2571684..2571980 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K9U08_RS12740 Protein ID WP_000650107.1
Coordinates 2571287..2571682 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U08_RS12730 (2567151) 2567151..2569409 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
K9U08_RS12735 (2569547) 2569547..2571154 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K9U08_RS12740 (2571287) 2571287..2571682 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K9U08_RS12745 (2571684) 2571684..2571980 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K9U08_RS12750 (2572185) 2572185..2572667 - 483 WP_000183505.1 GyrI-like domain-containing protein -
K9U08_RS12755 (2572720) 2572720..2573112 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K9U08_RS12760 (2573264) 2573264..2573923 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K9U08_RS12765 (2573920) 2573920..2575269 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K9U08_RS12770 (2575315) 2575315..2575647 - 333 WP_023149630.1 DUF2645 family protein -
K9U08_RS12775 (2575966) 2575966..2576547 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K9U08_RS12780 (2576578) 2576578..2576892 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T216658 WP_000415584.1 NZ_CP083503:c2571980-2571684 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T216658 NZ_CP113202:324949-325317 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT216658 WP_000650107.1 NZ_CP083503:c2571682-2571287 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT216658 NZ_CP113202:324731-324952 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References