Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 2531976..2532517 Replicon chromosome
Accession NZ_CP083492
Organism Escherichia coli strain elppa8

Toxin (Protein)


Gene name yafQ Uniprot ID Q47149
Locus tag K9U11_RS12170 Protein ID WP_000615983.1
Coordinates 2532239..2532517 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag K9U11_RS12165 Protein ID WP_228595107.1
Coordinates 2531976..2532236 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U11_RS12145 (2527651) 2527651..2528436 - 786 WP_000207552.1 putative lateral flagellar export/assembly protein LafU -
K9U11_RS12150 (2528408) 2528408..2530120 + 1713 Protein_2374 flagellar biosynthesis protein FlhA -
K9U11_RS12155 (2530344) 2530344..2530841 - 498 WP_000006255.1 REP-associated tyrosine transposase RayT -
K9U11_RS12160 (2531017) 2531017..2531766 - 750 WP_228595901.1 C40 family peptidase -
K9U11_RS12165 (2531976) 2531976..2532236 + 261 WP_228595107.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
K9U11_RS12170 (2532239) 2532239..2532517 + 279 WP_000615983.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
K9U11_RS12175 (2532673) 2532673..2533413 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
K9U11_RS12180 (2533384) 2533384..2534151 - 768 WP_000333380.1 class II glutamine amidotransferase -
K9U11_RS12185 (2534357) 2534357..2534935 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 2507517..2542381 34864


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10846.62 Da        Isoelectric Point: 9.9941

>T216574 WP_000615983.1 NZ_CP083492:2532239-2532517 [Escherichia coli]
MIQRDIEYSGQYSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T216574 NZ_CP113168:1973025-1973127 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9435.82 Da        Isoelectric Point: 5.0758

>AT216574 WP_228595107.1 NZ_CP083492:2531976-2532236 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLTGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGIDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT216574 NZ_CP113168:c1973134-1972989 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4Q2U

Antitoxin

Source ID Structure

References