Detailed information of TA system TA216556

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 42800..43064
• Replicon: plasmid unnamed9
• Accession: NZ_CP083490
• Organism: Escherichia coli strain elppa9

Toxin (Protein)

• Gene name: pndA
• Uniprot ID: U9Z417
• Locus tag: K9U12_RS26900
• Protein ID: WP_001387489.1
• Coordinates: 42800..42952 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	pndB
Locus tag	-
Coordinates	43004..43064 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U12_RS26870 (38066)	38066..40234	+	2169	WP_023518847.1	DotA/TraY family protein	-
K9U12_RS26875 (40305)	40305..40967	+	663	WP_000644796.1	plasmid IncI1-type surface exclusion protein ExcA	-
K9U12_RS26880 (41039)	41039..41248	-	210	WP_000062603.1	HEAT repeat domain-containing protein	-
K9U12_RS26885 (41640)	41640..41816	+	177	WP_001054897.1	hypothetical protein	-
K9U12_RS26890 (41881)	41881..42177	-	297	WP_011264046.1	DinQ-like type I toxin DqlB	-
K9U12_RS26895 (42477)	42477..42728	+	252	WP_001291964.1	hypothetical protein	-
K9U12_RS26900 (42800)	42800..42952	-	153	WP_001387489.1	Hok/Gef family protein	Toxin
- (43004)	43004..43064	+	61	NuclAT_0	-	Antitoxin
- (43004)	43004..43064	+	61	NuclAT_0	-	Antitoxin
- (43004)	43004..43064	+	61	NuclAT_0	-	Antitoxin
- (43004)	43004..43064	+	61	NuclAT_0	-	Antitoxin
K9U12_RS26905 (43273)	43273..43613	+	341	Protein_46	protein finQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..43613	43613

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (7-46)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5761.10 Da
• Isoelectric Point: 8.7948

>T216556 WP_001387489.1 NZ_CP083490:c42952-42800 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Nucleotide

• Length: 153 bp

>T216556 NZ_CP113165:1145940-1146350 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT216556 NZ_CP083490:43004-43064 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Structures

Toxin

• AlphaFold DB: U9Z417

Antitoxin