Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | prlF-yhaV (relBE)/YhaV-PrlF |
| Location | 3944185..3944984 | Replicon | chromosome |
| Accession | NZ_CP083481 | ||
| Organism | Escherichia coli strain elppa9 | ||
Toxin (Protein)
| Gene name | yhaV | Uniprot ID | D3GWU5 |
| Locus tag | K9U12_RS19175 | Protein ID | WP_000347272.1 |
| Coordinates | 3944185..3944649 (-) | Length | 155 a.a. |
Antitoxin (Protein)
| Gene name | prlF | Uniprot ID | S1EB98 |
| Locus tag | K9U12_RS19180 | Protein ID | WP_001307405.1 |
| Coordinates | 3944649..3944984 (-) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| K9U12_RS19145 (3939186) | 3939186..3939620 | - | 435 | WP_000948824.1 | PTS galactosamine/N-acetylgalactosamine transporter subunit IIA | - |
| K9U12_RS19150 (3939638) | 3939638..3940516 | - | 879 | WP_001298314.1 | PTS N-acetylgalactosamine transporter subunit IID | - |
| K9U12_RS19155 (3940506) | 3940506..3941285 | - | 780 | WP_000406214.1 | PTS N-acetylgalactosamine transporter subunit IIC | - |
| K9U12_RS19160 (3941296) | 3941296..3941769 | - | 474 | WP_001295547.1 | PTS N-acetylgalactosamine transporter subunit IIB | - |
| K9U12_RS19165 (3941792) | 3941792..3943072 | - | 1281 | WP_001521382.1 | tagatose-bisphosphate aldolase subunit KbaZ | - |
| K9U12_RS19170 (3943321) | 3943321..3944130 | + | 810 | WP_000072171.1 | aga operon transcriptional regulator AgaR | - |
| K9U12_RS19175 (3944185) | 3944185..3944649 | - | 465 | WP_000347272.1 | type II toxin-antitoxin system ribonuclease toxin YhaV | Toxin |
| K9U12_RS19180 (3944649) | 3944649..3944984 | - | 336 | WP_001307405.1 | type II toxin-antitoxin system antitoxin PrlF | Antitoxin |
| K9U12_RS19185 (3945133) | 3945133..3946704 | - | 1572 | WP_001273738.1 | galactarate dehydratase | - |
| K9U12_RS19190 (3947079) | 3947079..3948413 | + | 1335 | WP_000599651.1 | galactarate/glucarate/glycerate transporter GarP | - |
| K9U12_RS19195 (3948429) | 3948429..3949199 | + | 771 | WP_001058227.1 | 2-dehydro-3-deoxyglucarate aldolase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3944185..3955636 | 11451 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 155 a.a. Molecular weight: 17832.26 Da Isoelectric Point: 9.6924
>T216540 WP_000347272.1 NZ_CP083481:c3944649-3944185 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEEPH
Download Length: 465 bp
>T216540 NZ_CP113116:1009617-1010090 [Mycobacterium sp. Aquia_213]
ATGGCGAAACTTTCCGGATCCATCGACGTACCCCTGTCGCCAGAGCGGGCCTGGACGCACGCCTCCGATCTGTCCCGTTT
CAAGGACTGGCTGAGCATCCACCGGGTGTGGCGCAGCAAGCTGCCCGACGACCTGCAGAAGGGCACGGTCATCGAATCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAGTGGACGATCGTGCACTACAAGCCGCCGGAAGCCATGACGCTCAAC
GGAGACGGAGTCGGCGGGGTCAAGGTGAAGCTGATCGCGAAGGTCAAGCCGAAGGACGACGGATCGGTCGTCAGCTTCGA
CGTGCACCTTGGTGGTCCCGCGCTGTTCGGCCCGATCGGCATGATCGTGGCCGCCGCGCTGAGAAGCGACATCAACGAAT
CCCTGGAAAGATTCGTCACCGTGTTCACCGCTCCCGACCCCGGCCGCAACGGACATGGTGGCGCCCGCCGCTGA
ATGGCGAAACTTTCCGGATCCATCGACGTACCCCTGTCGCCAGAGCGGGCCTGGACGCACGCCTCCGATCTGTCCCGTTT
CAAGGACTGGCTGAGCATCCACCGGGTGTGGCGCAGCAAGCTGCCCGACGACCTGCAGAAGGGCACGGTCATCGAATCGA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAGTGGACGATCGTGCACTACAAGCCGCCGGAAGCCATGACGCTCAAC
GGAGACGGAGTCGGCGGGGTCAAGGTGAAGCTGATCGCGAAGGTCAAGCCGAAGGACGACGGATCGGTCGTCAGCTTCGA
CGTGCACCTTGGTGGTCCCGCGCTGTTCGGCCCGATCGGCATGATCGTGGCCGCCGCGCTGAGAAGCGACATCAACGAAT
CCCTGGAAAGATTCGTCACCGTGTTCACCGCTCCCGACCCCGGCCGCAACGGACATGGTGGCGCCCGCCGCTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12358.94 Da Isoelectric Point: 4.8616
>AT216540 WP_001307405.1 NZ_CP083481:c3944984-3944649 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE
Download Length: 336 bp
>AT216540 NZ_CP113116:1009424-1009612 [Mycobacterium sp. Aquia_213]
ATGGGATTCCTGGACAAGGCAAAGGACCTGTTGGCGCAGAACGCCGACAAGGTCGAGACCGCGATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACCCAGGGCAAGTACTCCGACACCATCCACAAGGTGCAGGAAGAGGCCAAGAAGGCGATCGACG
CCCAGGGCCCCGGCGACCAGCAGAACTGA
ATGGGATTCCTGGACAAGGCAAAGGACCTGTTGGCGCAGAACGCCGACAAGGTCGAGACCGCGATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACCCAGGGCAAGTACTCCGACACCATCCACAAGGTGCAGGAAGAGGCCAAGAAGGCGATCGACG
CCCAGGGCCCCGGCGACCAGCAGAACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A829KUD2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0XVC7 |