Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 62546..63081 Replicon plasmid pHJP554-1
Accession NZ_CP083474
Organism Enterococcus faecium strain HJP554

Toxin (Protein)


Gene name yoeB Uniprot ID Q3Y221
Locus tag LA367_RS14390 Protein ID WP_002305108.1
Coordinates 62809..63081 (+) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A133CED7
Locus tag LA367_RS14385 Protein ID WP_002303154.1
Coordinates 62546..62809 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA367_RS14360 58549..58821 + 273 WP_002305107.1 DUF3884 family protein -
LA367_RS14365 58842..59741 + 900 WP_002303235.1 aldose 1-epimerase family protein -
LA367_RS14375 61455..62018 + 564 Protein_60 IS6 family transposase -
LA367_RS14380 62024..62440 + 417 WP_002303153.1 hypothetical protein -
LA367_RS14385 62546..62809 + 264 WP_002303154.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LA367_RS14390 62809..63081 + 273 WP_002305108.1 Txe/YoeB family addiction module toxin Toxin
LA367_RS14395 63158..63487 + 330 WP_002292678.1 AbrB family transcriptional regulator -
LA367_RS14400 63477..63764 + 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
LA367_RS14405 64050..64907 + 858 WP_002292680.1 ParA family protein -
LA367_RS14410 64908..65456 + 549 WP_002292681.1 hypothetical protein -
LA367_RS14415 65753..66700 - 948 WP_002303155.1 sugar-binding domain-containing protein -
LA367_RS14420 66888..68075 + 1188 WP_002303156.1 NADP-dependent malic enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..196609 196609


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10806.28 Da        Isoelectric Point: 9.9080

>T216481 WP_002305108.1 NZ_CP083474:62809-63081 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T216481 NZ_CP113078:c1571933-1571544 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9886.16 Da        Isoelectric Point: 4.5370

>AT216481 WP_002303154.1 NZ_CP083474:62546-62809 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT216481 NZ_CP113078:c1572197-1571940 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A133CER3

Antitoxin

Source ID Structure
AlphaFold DB A0A133CED7

References