Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 62546..63081 | Replicon | plasmid pHJP554-1 |
Accession | NZ_CP083474 | ||
Organism | Enterococcus faecium strain HJP554 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | Q3Y221 |
Locus tag | LA367_RS14390 | Protein ID | WP_002305108.1 |
Coordinates | 62809..63081 (+) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A133CED7 |
Locus tag | LA367_RS14385 | Protein ID | WP_002303154.1 |
Coordinates | 62546..62809 (+) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LA367_RS14360 | 58549..58821 | + | 273 | WP_002305107.1 | DUF3884 family protein | - |
LA367_RS14365 | 58842..59741 | + | 900 | WP_002303235.1 | aldose 1-epimerase family protein | - |
LA367_RS14375 | 61455..62018 | + | 564 | Protein_60 | IS6 family transposase | - |
LA367_RS14380 | 62024..62440 | + | 417 | WP_002303153.1 | hypothetical protein | - |
LA367_RS14385 | 62546..62809 | + | 264 | WP_002303154.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
LA367_RS14390 | 62809..63081 | + | 273 | WP_002305108.1 | Txe/YoeB family addiction module toxin | Toxin |
LA367_RS14395 | 63158..63487 | + | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
LA367_RS14400 | 63477..63764 | + | 288 | WP_002300557.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
LA367_RS14405 | 64050..64907 | + | 858 | WP_002292680.1 | ParA family protein | - |
LA367_RS14410 | 64908..65456 | + | 549 | WP_002292681.1 | hypothetical protein | - |
LA367_RS14415 | 65753..66700 | - | 948 | WP_002303155.1 | sugar-binding domain-containing protein | - |
LA367_RS14420 | 66888..68075 | + | 1188 | WP_002303156.1 | NADP-dependent malic enzyme | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | - | 1..196609 | 196609 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10806.28 Da Isoelectric Point: 9.9080
>T216481 WP_002305108.1 NZ_CP083474:62809-63081 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTYEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T216481 NZ_CP113078:c1571933-1571544 [Acinetobacter baumannii]
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
TTGCTCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AATTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATAAGCTTTATTTTCTTTT
TAAAGCGTCCGCAACTTGCAAAAATTGCCTATTTAGATAAAAAACTATGGTCGCTTGCTTATCACTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAACACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAGCAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9886.16 Da Isoelectric Point: 4.5370
>AT216481 WP_002303154.1 NZ_CP083474:62546-62809 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDLKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT216481 NZ_CP113078:c1572197-1571940 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ATCCTGATTTACTCGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CER3 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A133CED7 |