Detailed information of TA system TA216445

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1030204..1030831
• Replicon: chromosome
• Accession: NZ_CP083444
• Organism: Bartonella taylorii strain IBS296

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: LAJ60_RS04560
• Protein ID: WP_252619292.1
• Coordinates: 1030517..1030831 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: LAJ60_RS04555
• Protein ID: WP_004861504.1
• Coordinates: 1030204..1030500 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAJ60_RS04515 (LAJ60_04525)	1025539..1025832	-	294	WP_252619284.1	HigA family addiction module antitoxin	-
LAJ60_RS04520 (LAJ60_04530)	1025849..1026130	-	282	WP_252619286.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LAJ60_RS04525 (LAJ60_04535)	1026312..1026763	+	452	Protein_873	single-stranded DNA-binding protein	-
LAJ60_RS04530 (LAJ60_04540)	1026775..1027311	+	537	WP_252619288.1	hypothetical protein	-
LAJ60_RS04535 (LAJ60_04545)	1027403..1027578	+	176	Protein_875	type II toxin-antitoxin system HicA family toxin	-
LAJ60_RS04540 (LAJ60_04550)	1027575..1027970	+	396	WP_252619290.1	type II toxin-antitoxin system HicB family antitoxin	-
LAJ60_RS04545 (LAJ60_04555)	1028454..1028780	+	327	Protein_877	hypothetical protein	-
LAJ60_RS04550 (LAJ60_04560)	1028777..1029360	+	584	Protein_878	hypothetical protein	-
LAJ60_RS04555 (LAJ60_04565)	1030204..1030500	-	297	WP_004861504.1	HigA family addiction module antitoxin	Antitoxin
LAJ60_RS04560 (LAJ60_04570)	1030517..1030831	-	315	WP_252619292.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LAJ60_RS04565 (LAJ60_04575)	1030884..1031432	+	549	WP_078692075.1	hypothetical protein	-
LAJ60_RS04570 (LAJ60_04580)	1031413..1032102	+	690	WP_078692073.1	phage baseplate assembly protein V	-
LAJ60_RS04575 (LAJ60_04585)	1032099..1032440	+	342	WP_004858808.1	GPW/gp25 family protein	-
LAJ60_RS04580 (LAJ60_04590)	1032437..1033264	+	828	WP_078692074.1	baseplate J/gp47 family protein	-
LAJ60_RS04585 (LAJ60_04595)	1033264..1034370	+	1107	WP_252619294.1	phage tail protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (16-104)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-93)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12196.11 Da
• Isoelectric Point: 9.8442

>T216445 WP_252619292.1 NZ_CP083444:c1030831-1030517 [Bartonella taylorii]
MIRKRTNKDDLVIEPFADKRCKDLLEGNPPKGFPTTLVRIAQRKLFMLDKAVDLKDLRSLPGNRLEALKGERKGQYSIRI
NDQFRVCFEWRSNGAYEVEIVDYH

Nucleotide

• Length: 315 bp

>T216445 NZ_CP113049:2695144-2695353 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11320.99 Da
• Isoelectric Point: 5.1546

>AT216445 WP_004861504.1 NZ_CP083444:c1030500-1030204 [Bartonella taylorii]
MKNYIAIHPGEILREEYLKEYALSAYALAKALNVPRTRIERIVAENSPVTPDTALRLAYFFDTTAEFWLNMQAAYDVSIL
QTEKADEFAKINKFECRV

Nucleotide

• Length: 297 bp

>AT216445 NZ_CP113049:2694839-2695132 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGACAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA