Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 346054..346640 Replicon chromosome
Accession NZ_CP083443
Organism Klebsiella pneumoniae strain KP1711R

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag K9870_RS01615 Protein ID WP_002920800.1
Coordinates 346272..346640 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag K9870_RS01610 Protein ID WP_004174006.1
Coordinates 346054..346275 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9870_RS01590 (342211) 342211..343137 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
K9870_RS01595 (343134) 343134..344411 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
K9870_RS01600 (344408) 344408..345175 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
K9870_RS01605 (345177) 345177..345890 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
K9870_RS01610 (346054) 346054..346275 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K9870_RS01615 (346272) 346272..346640 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
K9870_RS01620 (346913) 346913..348229 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
K9870_RS01625 (348336) 348336..349223 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
K9870_RS01630 (349220) 349220..350065 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
K9870_RS01635 (350067) 350067..351137 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 343134..351874 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T216424 WP_002920800.1 NZ_CP083443:346272-346640 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T216424 NZ_CP113044:c557479-557372 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT216424 WP_004174006.1 NZ_CP083443:346054-346275 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT216424 NZ_CP113044:557295-557355 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACTAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References