Detailed information of TA system TA216406

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 2505949..2506212
• Replicon: chromosome
• Accession: NZ_CP083434
• Organism: Staphylococcus aureus strain DC.RB_015

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: LAE57_RS12035
• Protein ID: WP_001802298.1
• Coordinates: 2505949..2506053 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF2
Locus tag	-
Coordinates	2506048..2506212 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAE57_RS12005	2501343..2502125	+	783	WP_000908190.1	ABC transporter ATP-binding protein	-
LAE57_RS12010	2502193..2503050	+	858	WP_000370919.1	HAD family hydrolase	-
LAE57_RS12015	2503244..2503458	-	215	Protein_2368	exotoxin	-
LAE57_RS12020	2503745..2503837	-	93	WP_031844941.1	hypothetical protein	-
LAE57_RS12025	2504126..2505262	+	1137	Protein_2370	SAP domain-containing protein	-
LAE57_RS12030	2505305..2505788	+	484	Protein_2371	recombinase family protein	-
LAE57_RS12035	2505949..2506053	+	105	WP_001802298.1	hypothetical protein	Toxin
-	2506048..2506212	-	165	-	-	Antitoxin
LAE57_RS12045	2506502..2507593	-	1092	WP_000495695.1	hypothetical protein	-
LAE57_RS12050	2507859..2508836	-	978	WP_000019732.1	CDF family zinc efflux transporter CzrB	-
LAE57_RS12055	2508838..2509158	-	321	WP_000139802.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
LAE57_RS12060	2509310..2509975	+	666	WP_001024088.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T216406 WP_001802298.1 NZ_CP083434:2505949-2506053 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T216406 NZ_CP113039:2006954-2007271 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTGATGTGTGATATTGAAGTGATAAAAAAAAAAATCAATGATGTAGCTATCAAACATGG
TTGGTTTGTTGAAGATAAATTTGTCAAAAATGAATTAGAAACAAAACAGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAGGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCAAAGAAATTAAAAATTACAGAGTAA

Antitoxin

Nucleotide

• Length: 165 bp

>AT216406 NZ_CP083434:c2506212-2506048 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAAATGCCGGTCAAAGCGAATAGAAGGT
TATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin