Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2219254..2219438 Replicon chromosome
Accession NZ_CP083434
Organism Staphylococcus aureus strain DC.RB_015

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag LAE57_RS10550 Protein ID WP_000482647.1
Coordinates 2219254..2219361 (+) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2219378..2219438 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAE57_RS10525 2214616..2215089 + 474 WP_000456483.1 GyrI-like domain-containing protein -
LAE57_RS10530 2215212..2216423 - 1212 WP_001191921.1 multidrug effflux MFS transporter -
LAE57_RS10535 2216606..2217265 - 660 WP_000831298.1 membrane protein -
LAE57_RS10540 2217325..2218467 - 1143 WP_001176863.1 glycerate kinase -
LAE57_RS10545 2218735..2219121 + 387 WP_000779353.1 flippase GtxA -
LAE57_RS10550 2219254..2219361 + 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
- 2219378..2219438 - 61 - - Antitoxin
LAE57_RS10555 2220009..2221721 + 1713 WP_001064821.1 ABC transporter ATP-binding protein -
LAE57_RS10560 2221797..2223530 + 1734 WP_000488493.1 ABC transporter ATP-binding protein -
LAE57_RS10565 2223761..2223928 + 168 WP_031845053.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T216403 WP_000482647.1 NZ_CP083434:2219254-2219361 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T216403 NZ_CP113039:c781369-781103 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 61 bp

>AT216403 NZ_CP083434:c2219438-2219378 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7

Antitoxin

Download structure file

References