Detailed information of TA system TA216398

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 18846..19201
• Replicon: chromosome
• Accession: NZ_CP083434
• Organism: Staphylococcus aureus strain DC.RB_015

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: LAE57_RS00100
• Protein ID: WP_011447039.1
• Coordinates: 18846..19022 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	19010..19201 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LAE57_RS00080	14081..17866	+	3786	WP_044557000.1	phage tail spike protein	-
LAE57_RS00085	17856..18008	+	153	WP_001153681.1	hypothetical protein	-
LAE57_RS00090	18055..18342	+	288	WP_001040261.1	hypothetical protein	-
LAE57_RS00095	18400..18696	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
LAE57_RS00100	18846..19022	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	19010..19201	-	192	-	-	Antitoxin
LAE57_RS00110	19251..19505	+	255	WP_000611512.1	phage holin	-
LAE57_RS00115	19517..20272	+	756	WP_000861038.1	CHAP domain-containing protein	-
LAE57_RS00120	20463..20954	+	492	WP_000920037.1	staphylokinase	-
LAE57_RS00125	21604..21939	+	336	Protein_25	SH3 domain-containing protein	-
LAE57_RS00130	22034..22483	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
LAE57_RS00135	23168..23518	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
LAE57_RS00140	23571..23831	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	1..26388	26387

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T216398 WP_011447039.1 NZ_CP083434:18846-19022 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T216398 NZ_CP113039:c334831-334655 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Nucleotide

• Length: 192 bp

>AT216398 NZ_CP083434:c19201-19010 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAAC
CAGCCAAAGTTAGCGATGGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin