Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3167713..3168406 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag LAJ62_RS15445 Protein ID WP_000415584.1
Coordinates 3168110..3168406 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag LAJ62_RS15440 Protein ID WP_000650107.1
Coordinates 3167713..3168108 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS15430 (3163577) 3163577..3165835 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
LAJ62_RS15435 (3165973) 3165973..3167580 - 1608 WP_133412436.1 ABC transporter substrate-binding protein -
LAJ62_RS15440 (3167713) 3167713..3168108 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
LAJ62_RS15445 (3168110) 3168110..3168406 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
LAJ62_RS15450 (3168611) 3168611..3169093 - 483 WP_000183505.1 GyrI-like domain-containing protein -
LAJ62_RS15455 (3169146) 3169146..3169538 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
LAJ62_RS15460 (3169690) 3169690..3170349 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
LAJ62_RS15465 (3170346) 3170346..3171695 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
LAJ62_RS15470 (3171741) 3171741..3172073 - 333 WP_000917684.1 DUF2645 family protein -
LAJ62_RS15475 (3172392) 3172392..3172973 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
LAJ62_RS15480 (3173004) 3173004..3173318 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T216386 WP_000415584.1 NZ_CP083410:c3168406-3168110 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T216386 NZ_CP113032:c2607076-2606969 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT216386 WP_000650107.1 NZ_CP083410:c3168108-3167713 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT216386 NZ_CP113032:2606892-2606952 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References