Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3655246..3655903 Replicon chromosome
Accession NZ_CP083403
Organism Enterobacter bugandensis strain XL95

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K9O83_RS17270 Protein ID WP_048957972.1
Coordinates 3655246..3655545 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K9O83_RS17275 Protein ID WP_047367527.1
Coordinates 3655556..3655903 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O83_RS17260 (K9O83_17200) 3651555..3653750 + 2196 WP_224065932.1 type I secretion system permease/ATPase -
K9O83_RS17265 (K9O83_17205) 3653761..3654930 + 1170 WP_088204896.1 HlyD family efflux transporter periplasmic adaptor subunit -
K9O83_RS17270 (K9O83_17210) 3655246..3655545 + 300 WP_048957972.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9O83_RS17275 (K9O83_17215) 3655556..3655903 + 348 WP_047367527.1 HigA family addiction module antitoxin Antitoxin
K9O83_RS17280 (K9O83_17220) 3655905..3656636 - 732 WP_047367526.1 helix-turn-helix transcriptional regulator -
K9O83_RS17285 (K9O83_17225) 3656734..3657042 + 309 WP_224065933.1 nuclear transport factor 2 family protein -
K9O83_RS17290 (K9O83_17230) 3657199..3658380 - 1182 WP_224065934.1 PLP-dependent aminotransferase family protein -
K9O83_RS17295 (K9O83_17235) 3658401..3659288 - 888 WP_063437854.1 LysR family transcriptional regulator -
K9O83_RS17300 (K9O83_17240) 3659386..3659988 + 603 WP_028014155.1 short chain dehydrogenase -
K9O83_RS17305 (K9O83_17245) 3659982..3660716 - 735 WP_224065935.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-102)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11538.15 Da        Isoelectric Point: 10.0104

>T216351 WP_048957972.1 NZ_CP083403:3655246-3655545 [Enterobacter bugandensis]
MINHFRDQWLKDFFLYGKSSNVIPSSLESALARKLDMINAATSHRELRSPPGNMYESLNPPLAGYSAIRVNRQYRLVFRW
SEGKADDLYLSPHKYTPYK

Download         Length: 300 bp

>T216351 NZ_CP113018:c2470857-2470564 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGATCAAAGCGAAAGTAACGCATAG

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13126.08 Da        Isoelectric Point: 7.0141

>AT216351 WP_047367527.1 NZ_CP083403:3655556-3655903 [Enterobacter bugandensis]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIRLAKAFDTTIEFWLNLQLNVD
VWEAQTNSRTQEELSRIKTIAEIMAKRKSGQPDVA

Download         Length: 348 bp

>AT216351 NZ_CP113018:c2471069-2470860 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References