216339

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 4838765..4840022 Replicon chromosome
Accession NZ_CP083387
Organism Arachidicoccus terrestris strain 5GH13-10

Toxin (Protein)


Gene name HipT Uniprot ID -
Locus tag K9M52_RS18785 Protein ID WP_224069980.1
Coordinates 4838765..4839598 (-) Length 278 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID -
Locus tag K9M52_RS18790 Protein ID WP_224069981.1
Coordinates 4839687..4840022 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9M52_RS18765 (K9M52_18780) 4835175..4835741 + 567 WP_224069977.1 hypothetical protein -
K9M52_RS19055 (K9M52_18785) 4836077..4836589 + 513 WP_262902412.1 PD-(D/E)XK nuclease family transposase -
K9M52_RS19060 (K9M52_18790) 4836601..4837086 + 486 WP_262902413.1 Rpn family recombination-promoting nuclease/putative transposase -
K9M52_RS18775 (K9M52_18795) 4837300..4837554 + 255 WP_224069978.1 hypothetical protein -
K9M52_RS18780 (K9M52_18800) 4837930..4838340 - 411 WP_224069979.1 glyoxalase/bleomycin resistance/extradiol dioxygenase family protein -
K9M52_RS18785 (K9M52_18805) 4838765..4839598 - 834 WP_224069980.1 HipA domain-containing protein Toxin
K9M52_RS18790 (K9M52_18810) 4839687..4840022 - 336 WP_224069981.1 HipA N-terminal domain-containing protein Antitoxin
K9M52_RS18795 (K9M52_18815) 4840395..4840541 - 147 WP_224069982.1 RagB/SusD family nutrient uptake outer membrane protein -
K9M52_RS18800 (K9M52_18820) 4840948..4841913 - 966 WP_224069983.1 hypothetical protein -
K9M52_RS18805 (K9M52_18825) 4842864..4843547 + 684 WP_224069984.1 type 1 glutamine amidotransferase domain-containing protein -
K9M52_RS18810 (K9M52_18830) 4843571..4844185 - 615 WP_224069985.1 SRPBCC domain-containing protein -
K9M52_RS18815 (K9M52_18835) 4844294..4844773 - 480 WP_224069986.1 SRPBCC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(21-241)

Antitoxin

HipA, N-terminal subdomain 1

(6-102)


Sequences

Toxin        


Download         Length: 278 a.a.        Molecular weight: 31695.64 Da        Isoelectric Point: 8.5870

>T216339 WP_224069980.1 NZ_CP083387:c4839598-4838765 [Arachidicoccus terrestris]
MELDQEKLNILAQFIVHERMAITGVQPKISLILNGEKGNKRLTSVGLWGDYILKPDTADFPCVPEVEDLTMHLAALFNIE
TAKHALIPTSTGQLAYITKRFDRQKGKKIHTEDLCQLSELLTEQKYKSSYERVGKLIRQYATNSGLVVIQYFRLVLFSFL
TGNNDMHLKNFSLVHTEKGILIAPAYDLLNVNLVYPEDKEDLALTLGGRKRKIKRSDVDLFAQNIGIANPVRDNIYKEFA
RCAKQVDDWIERSFLTDAYKENYSSIVTRKLKQIDLL

Download         Length: 834 bp

>T216339 NZ_CP113016:c2847925-2847773 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACTGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12713.53 Da        Isoelectric Point: 4.8498

>AT216339 WP_224069981.1 NZ_CP083387:c4840022-4839687 [Arachidicoccus terrestris]
MARQAKIYFQGNLAGYLVEGDNGYSFQYSLEYLAMKDAKPISLTLPLSEKTYHSNVLFPFFDGLIPEGWLLEIGEKHWKL
NPRDRFELLINLCRDTVGAVAVYPVEAETHE

Download         Length: 336 bp

>AT216339 NZ_CP113016:c2848549-2847950 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACGGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAATATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References