Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5814556..5815151 Replicon chromosome
Accession NZ_CP083366
Organism Pseudomonas aeruginosa strain PS1793

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag FLI66_RS27570 Protein ID WP_003113526.1
Coordinates 5814873..5815151 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag FLI66_RS27565 Protein ID WP_003133769.1
Coordinates 5814556..5814861 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FLI66_RS27530 (FLI66_27515) 5809697..5810545 + 849 WP_003095007.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
FLI66_RS27540 (FLI66_27525) 5810712..5811653 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
FLI66_RS27545 (FLI66_27530) 5811770..5812384 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
FLI66_RS27550 (FLI66_27535) 5812426..5813010 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
FLI66_RS27555 (FLI66_27540) 5813051..5814151 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
FLI66_RS27565 (FLI66_27550) 5814556..5814861 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
FLI66_RS27570 (FLI66_27555) 5814873..5815151 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FLI66_RS27575 5815204..5815332 - 129 Protein_5454 integrase -
FLI66_RS27580 (FLI66_27560) 5815480..5817708 + 2229 WP_019485341.1 TonB-dependent receptor -
FLI66_RS27585 (FLI66_27565) 5817778..5818425 - 648 WP_003095021.1 carbonate dehydratase -
FLI66_RS27590 (FLI66_27570) 5818487..5819725 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T216322 WP_003113526.1 NZ_CP083366:c5815151-5814873 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T216322 NZ_CP113015:c264646-264539 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTATAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT216322 WP_003133769.1 NZ_CP083366:c5814861-5814556 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp

>AT216322 NZ_CP113015:264462-264522 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References