Detailed information of TA system TA216283

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4481424..4481644
• Replicon: chromosome
• Accession: NZ_CP083274
• Organism: Escherichia coli strain Rosetta2-DE3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: K6U01_RS21820
• Protein ID: WP_000170963.1
• Coordinates: 4481424..4481531 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4481578..4481644 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6U01_RS21755	4477779..4478027	-	249	WP_223717396.1	Bor family protein	-
K6U01_RS21760	4478388..4478459	-	72	Protein_4272	DUF3950 domain-containing protein	-
K6U01_RS21765	4478462..4479106	+	645	Protein_4273	RHS repeat protein	-
K6U01_RS21775	4479390..4479740	-	351	Protein_4274	site-specific integrase	-
K6U01_RS21785	4479947..4480129	+	183	WP_001228695.1	prophage lysis lipoprotein RzoD	-
K6U01_RS21795	4480220..4480354	-	135	Protein_4276	serum resistance lipoprotein Bor	-
K6U01_RS21800	4480407..4480526	+	120	Protein_4277	IS3 family transposase	-
K6U01_RS21805	4480624..4480776	+	153	WP_000956455.1	type I toxin-antitoxin system toxin HokE	-
K6U01_RS21820	4481424..4481531	-	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4481578..4481644	+	67	-	-	Antitoxin
K6U01_RS21825	4481808..4482236	-	429	Protein_4280	ISAs1 family transposase	-
K6U01_RS21830	4482512..4482667	+	156	Protein_4281	YlcI/YnfO family protein	-
K6U01_RS21845	4483102..4483509	-	408	Protein_4282	colanic acid biosynthesis phosphomannomutase CpsG	-
K6U01_RS21850	4483590..4483805	+	216	WP_000188870.1	hypothetical protein	-
K6U01_RS21855	4483877..4484218	-	342	Protein_4284	colanic acid biosynthesis phosphomannomutase CpsG	-
K6U01_RS21865	4484518..4484793	-	276	Protein_4285	RHS domain-containing protein	-
K6U01_RS21870	4484794..4485066	+	273	Protein_4286	DNA-packaging protein	-
K6U01_RS21885	4485578..4485769	-	192	Protein_4287	GTP-binding protein	-
K6U01_RS21890	4486294..4486515	+	222	Protein_4288	phosphomannomutase CpsG	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	tufA	4468229..4482236	14007

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T216283 WP_000170963.1 NZ_CP083274:c4481531-4481424 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T216283 NZ_CP112997:3780057-3780467 [Mycobacterium tuberculosis variant bovis]
GTGATCTATATGGACACCTCGGCCCTGACTAAGCTGCTCATCTCCGAGCCCGAGACGACCGAACTGCGGACATGGCTGAC
CGCGCAAAGCGGCCAGGGCGAGGACGCGGCGACAAGCACCCTTGGCCGGGTCGAGTTGATGAGAGTCGTTGCCCGATACG
GACAACCAGGCCAAACTGAGCGTGCGCGTTACCTACTCGACGGGCTCGACATCCTCCCGCTCACCGAACCGGTGATCGGT
CTAGCTGAAACGATCGGACCGGCCACCCTACGTTCTCTCGACGCGATTCACCTCGCGGCCGCAGCCCAGATCAAGCGGGA
ACTGACAGCCTTCGTCACCTACGACCACCGATTGTTGAGCGGATGCCGTGAGGTCGGCTTCGTCACCGCCTCACCCGGCG
CAGTCCGGTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT216283 NZ_CP083274:4481578-4481644 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin