Detailed information of TA system TA216273

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2496652..2496872
• Replicon: chromosome
• Accession: NZ_CP083274
• Organism: Escherichia coli strain Rosetta2-DE3

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: K6U01_RS12025
• Protein ID: WP_000170963.1
• Coordinates: 2496765..2496872 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2496652..2496718 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6U01_RS12005	2492725..2493924	+	1200	WP_000284714.1	lipoprotein-releasing ABC transporter permease subunit LolC	-
K6U01_RS12010	2493917..2494618	+	702	WP_001033695.1	lipoprotein-releasing ABC transporter ATP-binding protein LolD	-
K6U01_RS12015	2494618..2495862	+	1245	WP_001251384.1	lipoprotein-releasing ABC transporter permease subunit LolE	-
K6U01_RS12020	2495891..2496319	+	429	Protein_2372	ROK family protein	-
-	2496652..2496718	-	67	-	-	Antitoxin
K6U01_RS12025	2496765..2496872	+	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
K6U01_RS12030	2497019..2497873	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
K6U01_RS12035	2497909..2498718	-	810	WP_001257044.1	invasion regulator SirB1	-
K6U01_RS12040	2498722..2499114	-	393	WP_000200373.1	invasion regulator SirB2	-
K6U01_RS12045	2499111..2499944	-	834	WP_000456454.1	peptide chain release factor N(5)-glutamine methyltransferase	-
K6U01_RS12050	2499944..2501026	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T216273 WP_000170963.1 NZ_CP083274:2496765-2496872 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T216273 NZ_CP112997:c3030712-3030317 [Mycobacterium tuberculosis variant bovis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin

Nucleotide

• Length: 67 bp

>AT216273 NZ_CP083274:c2496718-2496652 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin