Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 998263..998956 Replicon chromosome
Accession NZ_CP083274
Organism Escherichia coli strain Rosetta2-DE3

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K6U01_RS04775 Protein ID WP_000415584.1
Coordinates 998660..998956 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K6U01_RS04770 Protein ID WP_000650107.1
Coordinates 998263..998658 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K6U01_RS04760 (994127) 994127..996385 - 2259 WP_001281877.1 DNA topoisomerase IV subunit A -
K6U01_RS04765 (996523) 996523..998130 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K6U01_RS04770 (998263) 998263..998658 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K6U01_RS04775 (998660) 998660..998956 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K6U01_RS04780 (999161) 999161..999643 - 483 WP_000183505.1 GyrI-like domain-containing protein -
K6U01_RS04785 (999696) 999696..1000088 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K6U01_RS04790 (1000240) 1000240..1000899 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K6U01_RS04795 (1000896) 1000896..1002245 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K6U01_RS04800 (1002291) 1002291..1002623 - 333 WP_000917684.1 DUF2645 family protein -
K6U01_RS04805 (1002942) 1002942..1003523 + 582 WP_000072420.1 NADPH:quinone oxidoreductase MdaB -
K6U01_RS04810 (1003554) 1003554..1003868 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T216262 WP_000415584.1 NZ_CP083274:c998956-998660 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T216262 NZ_CP112997:2240022-2240420 [Mycobacterium tuberculosis variant bovis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT216262 WP_000650107.1 NZ_CP083274:c998658-998263 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT216262 NZ_CP112997:2239794-2240021 [Mycobacterium tuberculosis variant bovis]
GTGTCACGGACCAACATCGAGATCGACGACGAACTCGTGGCCGCCGCACAGCGGATGTACCGACTCGATTCCAAGCGAAG
TGCCGTCGACCTCGCGCTGCGCCGGCTCGTGGGTGAACCGTTGGGCCGCGATGAGGCTTTGGCGCTGCAGGGCAGCGGTT
TCGACTTCAGCGACGATGAGATCGAATCGTTCTCGGATACGGACCGCAAGCTCGCCGACGAGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References