Detailed information of TA system TA216248

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 2369883..2370103
• Replicon: chromosome
• Accession: NZ_CP083273
• Organism: Escherichia coli strain BL21-RIPL

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: J7R083
• Locus tag: K9U36_RS11430
• Protein ID: WP_000170963.1
• Coordinates: 2369996..2370103 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	2369883..2369949 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U36_RS11405	2365283..2366509	+	1227	WP_000090611.1	phosphopentomutase	-
K9U36_RS11410	2366506..2367384	+	879	WP_000007010.1	phosphotriesterase-related protein	-
K9U36_RS11415	2367395..2367748	+	354	WP_000719728.1	DUF2620 domain-containing protein	-
K9U36_RS11420	2367760..2369064	+	1305	WP_000366852.1	YhfT family protein	-
K9U36_RS11425	2369076..2369549	+	474	Protein_2255	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
-	2369883..2369949	-	67	-	-	Antitoxin
K9U36_RS11430	2369996..2370103	+	108	WP_000170963.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
K9U36_RS11435	2370250..2371104	-	855	WP_000811065.1	3-deoxy-8-phosphooctulonate synthase	-
K9U36_RS11440	2371140..2371949	-	810	WP_001257044.1	invasion regulator SirB1	-
K9U36_RS11445	2371953..2372345	-	393	WP_000200373.1	invasion regulator SirB2	-
K9U36_RS11450	2372342..2373175	-	834	WP_000456454.1	peptide chain release factor N(5)-glutamine methyltransferase	-
K9U36_RS11455	2373175..2374257	-	1083	WP_000804726.1	peptide chain release factor 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3971.74 Da
• Isoelectric Point: 11.4779

>T216248 WP_000170963.1 NZ_CP083273:2369996-2370103 [Escherichia coli]
MTLAQFAMTFWHDLAAPILAGIITAAIVGWWRNRK

Nucleotide

• Length: 108 bp

>T216248 NZ_CP112997:1384142-1384573 [Mycobacterium tuberculosis variant bovis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin

Nucleotide

• Length: 67 bp

>AT216248 NZ_CP083273:c2369949-2369883 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin