Detailed information of TA system TA216206

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2572897..2573081
• Replicon: chromosome
• Accession: NZ_CP083259
• Organism: Staphylococcus aureus strain HL25274

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: K3A98_RS12845
• Protein ID: WP_000482647.1
• Coordinates: 2572974..2573081 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2572897..2572957 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3A98_RS12830	2568407..2568574	-	168	WP_031875065.1	hypothetical protein	-
K3A98_RS12835	2568805..2570538	-	1734	WP_000488491.1	ABC transporter ATP-binding protein	-
K3A98_RS12840	2570587..2572326	-	1740	WP_001064832.1	ABC transporter ATP-binding protein	-
-	2572897..2572957	+	61	-	-	Antitoxin
K3A98_RS12845	2572974..2573081	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
K3A98_RS12850	2573215..2573601	-	387	WP_000779354.1	flippase GtxA	-
K3A98_RS12855	2573869..2575011	+	1143	WP_031875064.1	glycerate kinase	-
K3A98_RS12860	2575071..2575730	+	660	WP_000831298.1	membrane protein	-
K3A98_RS12865	2575910..2577121	+	1212	WP_001191975.1	multidrug effflux MFS transporter	-
K3A98_RS12870	2577244..2577717	-	474	WP_000456490.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T216206 WP_000482647.1 NZ_CP083259:c2573081-2572974 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T216206 NZ_CP112996:2241720-2242118 [Mycobacterium tuberculosis variant bovis]
ATGATCGTCGACACCTCGGTCTGGATCGCATATCTCTCCACGTCAGAGTCGTTGGCCAGTCGCTGGCTAGCCGATCGCAT
TGCCGCTGACTCGACGGTGATCGTGCCCGAGGTGGTGATGATGGAGCTGCTGATCGGTAAGACCGATGAGGACACCGCCG
CACTGCGCCGACGGCTCCTGCAGCGATTCGCTATCGAACCGCTGGCCCCGGTCCGCGACGCGGAAGATGCCGCCGCCATT
CACCGGCGCTGTCGTCGCGGCGGCGACACCGTACGCAGCCTGATCGATTGCCAGGTGGCCGCGATGGCGTTGCGGATCGG
GGTCGCCGTGGCGCATCGTGATCGCGACTACGAGGCGATCCGCACACATTGCGGACTACGCACCGAGCCGTTGTTCTGA

Antitoxin

Nucleotide

• Length: 61 bp

>AT216206 NZ_CP083259:2572897-2572957 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin