Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2058566..2058980 Replicon chromosome
Accession NZ_CP083259
Organism Staphylococcus aureus strain HL25274

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag K3A98_RS10275 Protein ID WP_001065046.1
Coordinates 2058729..2058980 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K3A98_RS10270 Protein ID WP_000028424.1
Coordinates 2058566..2058739 (-) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A98_RS10220 (2054224) 2054224..2055519 - 1296 WP_000273012.1 PBSX family phage terminase large subunit -
K3A98_RS10225 (2055522) 2055522..2056016 - 495 WP_001038245.1 terminase small subunit -
K3A98_RS10230 (2056203) 2056203..2056622 - 420 WP_000058632.1 transcriptional regulator -
K3A98_RS10235 (2056637) 2056637..2056783 - 147 WP_000990006.1 hypothetical protein -
K3A98_RS10240 (2056784) 2056784..2056957 - 174 WP_223671374.1 transcriptional activator RinB -
K3A98_RS10245 (2056954) 2056954..2057340 - 387 WP_223671375.1 DUF1523 family protein -
K3A98_RS10250 (2057337) 2057337..2057543 - 207 WP_000195803.1 DUF1381 domain-containing protein -
K3A98_RS10255 (2057580) 2057580..2058107 - 528 WP_072473165.1 dUTPase -
K3A98_RS10260 (2058122) 2058122..2058283 - 162 WP_000889683.1 hypothetical protein -
K3A98_RS10265 (2058284) 2058284..2058565 - 282 WP_000454994.1 hypothetical protein -
K3A98_RS10270 (2058566) 2058566..2058739 - 174 WP_000028424.1 hypothetical protein Antitoxin
K3A98_RS10275 (2058729) 2058729..2058980 - 252 WP_001065046.1 DUF1024 family protein Toxin
K3A98_RS10280 (2058995) 2058995..2059237 - 243 WP_000131377.1 phi PVL orf 51-like protein -
K3A98_RS10285 (2059241) 2059241..2059609 - 369 WP_000101270.1 SA1788 family PVL leukocidin-associated protein -
K3A98_RS10290 (2059622) 2059622..2059931 - 310 Protein_1999 RusA family crossover junction endodeoxyribonuclease -
K3A98_RS10295 (2059940) 2059940..2060158 - 219 WP_000338530.1 hypothetical protein -
K3A98_RS10300 (2060165) 2060165..2061049 - 885 WP_000148316.1 DnaD domain protein -
K3A98_RS10305 (2061079) 2061079..2061549 - 471 WP_098691726.1 single-stranded DNA-binding protein -
K3A98_RS10310 (2061550) 2061550..2062167 - 618 WP_078065545.1 MBL fold metallo-hydrolase -
K3A98_RS10315 (2062248) 2062248..2063168 - 921 WP_223671376.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2022724..2072730 50006


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9377.26 Da        Isoelectric Point: 3.7128

>T216204 WP_001065046.1 NZ_CP083259:c2058980-2058729 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T216204 NZ_CP112996:c2216746-2216186 [Mycobacterium tuberculosis variant bovis]
GTGAGCGATGCCCTCGATGAAGGGCTCGTCCAGCGTATCGACGCACGCGGAACAATTGAGTGGTCGGAAACGTGCTACCG
GTATACCGGCGCGCACCGTGACGCCTTGTCCGGTGAGGGCGCGCGCAGATTCGGAGGCAGGTGGAATCCGCCGCTGCTCT
TTCCGGCGATCTATCTTGCTGATTCCGCCCAAGCCTGCATGGTTGAGGTGGAACGGGCGGCGCAAGCGGCTTCAACGACC
GCAGAGAAGATGCTCGAGGCGGCCTACCGACTACACACGATCGACGTCACGGACCTGGCCGTCCTCGATCTGACAACCCC
GCAAGCTCGGGAAGCCGTGGGGCTCGAGAACGACGACATCTATGGCGACGACTGGTCAGGGTGCCAGGCGGTCGGACATG
CGGCCTGGTTCTTGCACATGCAAGGTGTCCTCGTGCCGGCGGCGGGCGGTGTCGGCCTCGTTGTCACCGCGTATGAACAG
CGAACTCGGCCGGGCCAACTACAACTGCGACAAAGCGTCGATCTGACGCCTGCTCTTTACCAAGAACTTCGAGCCACGTA
G

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT216204 WP_000028424.1 NZ_CP083259:c2058739-2058566 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT216204 NZ_CP112996:c2217084-2216743 [Mycobacterium tuberculosis variant bovis]
ATGGGAGTAAATGTGCTCGCCTCGACCGTGTCGGGTGCGATCGAGCGCTTGGGATTGACCTACGAGGAAGTCGGTGACAT
CGTCGATGCCTCGCCGCGTTCCGTGGCGCGATGGACCGCAGGTCAGGTGGTTCCCCAACGCCTCAACAAGCAACGACTTA
TCGAGCTGGCCTATGTCGCCGACGCCCTCGCGGAAGTGCTGCCGCGTGACCAGGCGAACGTGTGGATGTTTTCGCCGAAT
CGGTTACTGGAACACCGCAAGCCTGCCGACCTCGTGCGAGACGGCGAGTACCAACGCGTGTTGGCGCTCATCGACGCGAT
GGCGGAGGGAGTGTTCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References