Detailed information of TA system TA216199

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 883840..884178
• Replicon: chromosome
• Accession: NZ_CP083259
• Organism: Staphylococcus aureus strain HL25274

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K3A98_RS04455
• Protein ID: WP_011447039.1
• Coordinates: 883840..884016 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	884004..884178 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3A98_RS04435	879075..882860	+	3786	WP_000582165.1	phage tail spike protein	-
K3A98_RS04440	882850..883002	+	153	WP_001153681.1	hypothetical protein	-
K3A98_RS04445	883049..883336	+	288	WP_001040261.1	hypothetical protein	-
K3A98_RS04450	883394..883690	+	297	WP_000539688.1	DUF2951 domain-containing protein	-
K3A98_RS04455	883840..884016	+	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	884004..884178	-	175	-	-	Antitoxin
K3A98_RS04465	884228..884482	+	255	WP_000611512.1	phage holin	-
K3A98_RS04470	884494..885249	+	756	WP_000861038.1	CHAP domain-containing protein	-
K3A98_RS04475	885440..885931	+	492	WP_000919350.1	staphylokinase	-
K3A98_RS04480	886581..886916	+	336	Protein_880	SH3 domain-containing protein	-
K3A98_RS04485	887011..887460	-	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K3A98_RS04490	888145..888495	+	351	WP_000702263.1	complement inhibitor SCIN-A	-
K3A98_RS04495	888548..888808	-	261	WP_001791826.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	sak / chp / scn	846813..888495	41682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T216199 WP_011447039.1 NZ_CP083259:883840-884016 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T216199 NZ_CP112996:1957780-1958028 [Mycobacterium tuberculosis variant bovis]
ATGGTGATCGATACCTCTGCGCTGGTCGCGATGCTCAACGATGAACCCGAGGCGCAACGGTTCGAGATAGCCGTGGCAGC
AGACCACGTTTGGCTGATGTCGACGGCGTCATATCCGGAGATGGCGACCGTGATCGAAACACGCTTCGGGGAACCGGGGG
GACGTGAACCCAAGGTCAGCGGCCAGCCTCTCCTCTATACGGGTGACGATTTCGCATGTATCGATATTCGCGCGGTTCTC
GCCGGCTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT216199 NZ_CP083259:c884178-884004 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin