Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2663599..2664184 Replicon chromosome
Accession NZ_CP083239
Organism Ancylobacter polymorphus strain ZM13

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag K9D25_RS12580 Protein ID WP_244375631.1
Coordinates 2663599..2663880 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K9D25_RS12585 Protein ID WP_244375633.1
Coordinates 2663891..2664184 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9D25_RS12560 (K9D25_12560) 2659985..2660836 - 852 WP_244375623.1 cytochrome c1 -
K9D25_RS12565 (K9D25_12565) 2660847..2662121 - 1275 WP_244375625.1 cytochrome b/b6 -
K9D25_RS12570 (K9D25_12570) 2662146..2662706 - 561 WP_244375627.1 ubiquinol-cytochrome c reductase iron-sulfur subunit -
K9D25_RS12575 (K9D25_12575) 2663066..2663539 + 474 WP_244375629.1 tRNA (cytidine(34)-2'-O)-methyltransferase -
K9D25_RS12580 (K9D25_12580) 2663599..2663880 + 282 WP_244375631.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9D25_RS12585 (K9D25_12585) 2663891..2664184 + 294 WP_244375633.1 HigA family addiction module antitoxin Antitoxin
K9D25_RS12590 (K9D25_12590) 2664281..2664784 + 504 WP_244375635.1 transcription elongation factor GreA -
K9D25_RS12595 (K9D25_12595) 2664792..2666654 - 1863 WP_244375637.1 ABC transporter ATP-binding protein -
K9D25_RS12600 (K9D25_12600) 2666805..2667500 + 696 WP_244375639.1 VIT family protein -
K9D25_RS12605 (K9D25_12605) 2667569..2668462 + 894 WP_244375641.1 oxygen-dependent coproporphyrinogen oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10563.14 Da        Isoelectric Point: 10.5747

>T216189 WP_244375631.1 NZ_CP083239:2663599-2663880 [Ancylobacter polymorphus]
MIVSFRDKRTEAVWSGRVGKGFPADLVRVAQRRLAMLNAAVTLESLRVPPANRLEALKGDRAGQHSIRINDQFRICFLWR
EGNAAEVEITDYH

Download         Length: 282 bp

>T216189 NZ_CP112996:1168211-1169092 [Mycobacterium tuberculosis variant bovis]
GTGACCAAGCCCTATTCGTCGCCGCCAACGAACCTGCGCTCACTACGAGATCGGCTCACCCAAGTAGCGGAACGGCAAGG
TGTCGTGTTCGGTCGACTGCAGCGGCATGTCGCGATGATTGTTGTCGCACAGTTCGCGGCCACGCTCACCGACGACACCG
GCGCTCCGCTGCTGTTGGTCAAAGGCGGATCGTCGCTGGAACTGCGCCGGGGAATTCCCGATTCGCGGACCTCCAAAGAC
TTCGACACGGTCGCACGTCGCGATATCGAATTAATCCATGAACAGCTCGCTGACGCGGGCGAGACGGGGTGGGAAGGATT
CACTGCAATCTTCACCGCCCCCGAAGAAATCGATGTTCCTGGTATGCCGGTCAAGCCGCGCCGATTCACCGCCAAGCTGA
GCTACCGAGGCCGGGCTTTCGCAACTGTTCCGATCGAGGTCTCCTCCGTCGAAGCCGGCAATGCCGACCAATTCGACACC
CTCACCTCAGACGCGCTCGGCCTCGTGGGCGTACCCGCAGCAGTCGCCGTACCCTGCATGACCATTCCCTGGCAAATCGC
GCAGAAGCTGCACGCAGTAACTGCCGTGCTCGAAGAACCGAAGGTCAACGACCGCGCTCACGACCTGGTGGACTTGCAGC
TTCTTGAAGGACTGTTGCTCGATGCCGACCTCATGCCGACGCGCAGCGCGTGCATCGCGATATTCGAAGCGCGCGCCCAG
CATCCTTGGCCACCGAGAGTCGCCACGCTGCCGCACTGGCCGCTGATCTATGCAGGTGCGCTGGAGGGGCTTGACCACCT
TGAACTCGCCAGGACGGTCGACGCGGCGGCCCAGGCAGTGCAGCGATTCGTTGCGCGGATTGATCGGGCGACGAAAAGAT
GA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10858.57 Da        Isoelectric Point: 7.2039

>AT216189 WP_244375633.1 NZ_CP083239:2663891-2664184 [Ancylobacter polymorphus]
MIGPTPPIHPGEILREEFLLPLGLRPYGLAKALHVPRTRIERLAREDVPVTADTALRLGRYFGTGPEFWMNLQTAFDLAK
TQAERPELANITPREAA

Download         Length: 294 bp

>AT216189 NZ_CP112996:1167591-1168214 [Mycobacterium tuberculosis variant bovis]
TTGTGTGCAAAACCGTATCTAATTGATACGATTGCGCACATGGCTATCTGGGATCGCCTCGTCGAGGTTGCCGCCGAGCA
ACATGGCTACGTCACGACTCGCGATGCGCGAGACATCGGCGTCGACCCTGTGCAGCTCCGCCTCCTAGCGGGGCGCGGAC
GTCTTGAGCGTGTCGGCCGAGGTGTGTACCGGGTGCCCGTGCTGCCGCGTGGTGAGCACGACGATCTCGCAGCCGCAGTG
TCGTGGACTTTGGGGCGTGGCGTTATCTCGCATGAGTCGGCCTTGGCGCTTCATGCCCTCGCTGACGTGAACCCGTCGCG
CATCCATCTCACCGTCCCGCGCAACAACCATCCGCGTGCGGCCGGGGGCGAGCTGTACCGAGTTCACCGCCGCGACCTCC
AGGCAGCCCACGTCACTTCGGTCGACGGAATACCCGTCACGACGGTTGCGCGCACCATCAAAGACTGCGTGAAGACGGGC
ACGGATCCTTATCAGCTTCGGGCCGCGATCGAGCGAGCCGAAGCCGAGGGCACGCTTCGTCGTGGGTCAGCAGCTGAGCT
ACGCGCTGCGCTCGATGAGACCACTGCCGGATTACGCGCTCGGCCGAAGCGAGCATCGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References