Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 14947..15598 Replicon plasmid unnamed
Accession NZ_CP083182
Organism Acinetobacter baumannii strain AB43

Toxin (Protein)


Gene name higB Uniprot ID N8YFZ1
Locus tag K9O37_RS18850 Protein ID WP_000269904.1
Coordinates 14947..15303 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K9O37_RS18855 Protein ID WP_024436604.1
Coordinates 15296..15598 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9O37_RS18820 (K9O37_18735) 11185..12117 + 933 WP_147508592.1 replication initiation protein RepM -
K9O37_RS18825 (K9O37_18740) 12196..12717 + 522 WP_004676375.1 plasmid replication DNA-binding protein -
K9O37_RS18830 (K9O37_18745) 12927..13187 - 261 WP_004698336.1 hypothetical protein -
K9O37_RS18835 (K9O37_18750) 13354..13674 + 321 WP_004698338.1 type II toxin-antitoxin system RelE/ParE family toxin -
K9O37_RS18840 (K9O37_18755) 13667..13939 + 273 WP_000369781.1 NadS family protein -
K9O37_RS18845 (K9O37_18760) 14019..14339 - 321 WP_163078293.1 DUF6176 family protein -
K9O37_RS18850 (K9O37_18765) 14947..15303 + 357 WP_000269904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9O37_RS18855 (K9O37_18770) 15296..15598 + 303 WP_024436604.1 XRE family transcriptional regulator Antitoxin
K9O37_RS18860 (K9O37_18775) 15591..15800 + 210 WP_000069475.1 hypothetical protein -
K9O37_RS18865 (K9O37_18780) 15975..16493 + 519 WP_000447196.1 tetratricopeptide repeat protein -
K9O37_RS18870 (K9O37_18785) 16532..17044 + 513 WP_024436968.1 SMI1/KNR4 family protein -
K9O37_RS18875 (K9O37_18790) 17227..17655 + 429 WP_016653412.1 hypothetical protein -
K9O37_RS18880 (K9O37_18795) 17880..18107 - 228 Protein_23 recombinase family protein -
K9O37_RS18885 (K9O37_18800) 18162..18866 - 705 WP_004741406.1 IS6-like element IS1006 family transposase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..104309 104309


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-105)

Antitoxin

(14-89)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13488.42 Da        Isoelectric Point: 5.7104

>T216185 WP_000269904.1 NZ_CP083182:14947-15303 [Acinetobacter baumannii]
MWTVITTDLFNEWLEQQDEATQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKSNKKRFYTEMLAIADEQYALHLSTLGDQSNG

Download         Length: 357 bp

>T216185 NZ_CP112996:c757444-757007 [Mycobacterium tuberculosis variant bovis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11181.00 Da        Isoelectric Point: 7.3198

>AT216185 WP_024436604.1 NZ_CP083182:15296-15598 [Acinetobacter baumannii]
MAKSLQELLASRSPESQTRIQKMADELLLESQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Download         Length: 303 bp

>AT216185 NZ_CP112996:c756897-756652 [Mycobacterium tuberculosis variant bovis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB N8YFZ1


Antitoxin

Source ID Structure

References